2enm: Difference between revisions
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==Solution structure of the SH3 domain from mouse sorting nexin-9== | ==Solution structure of the SH3 domain from mouse sorting nexin-9== | ||
<StructureSection load='2enm' size='340' side='right'caption='[[2enm | <StructureSection load='2enm' size='340' side='right'caption='[[2enm]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2enm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2enm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ENM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ENM FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2enm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2enm OCA], [https://pdbe.org/2enm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2enm RCSB], [https://www.ebi.ac.uk/pdbsum/2enm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2enm ProSAT], [https://www.topsan.org/Proteins/RSGI/2enm TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2enm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2enm OCA], [https://pdbe.org/2enm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2enm RCSB], [https://www.ebi.ac.uk/pdbsum/2enm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2enm ProSAT], [https://www.topsan.org/Proteins/RSGI/2enm TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/SNX9_MOUSE SNX9_MOUSE] May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Hayashi | [[Category: Hayashi F]] | ||
[[Category: Kurosaki | [[Category: Kurosaki C]] | ||
[[Category: Wakabayashi M]] | |||
[[Category: Wakabayashi | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | [[Category: Yoshida M]] | ||
[[Category: Yoshida | |||