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==Solution structure of the chromo domain of Mortality factor 4-like protein 1 from human== | ==Solution structure of the chromo domain of Mortality factor 4-like protein 1 from human== | ||
<StructureSection load='2efi' size='340' side='right'caption='[[2efi | <StructureSection load='2efi' size='340' side='right'caption='[[2efi]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2efi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2efi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EFI FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2efi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2efi OCA], [https://pdbe.org/2efi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2efi RCSB], [https://www.ebi.ac.uk/pdbsum/2efi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2efi ProSAT], [https://www.topsan.org/Proteins/RSGI/2efi TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2efi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2efi OCA], [https://pdbe.org/2efi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2efi RCSB], [https://www.ebi.ac.uk/pdbsum/2efi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2efi ProSAT], [https://www.topsan.org/Proteins/RSGI/2efi TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/MO4L1_HUMAN MO4L1_HUMAN] Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.<ref>PMID:14966270</ref> <ref>PMID:20332121</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Harada | [[Category: Harada T]] | ||
[[Category: Kigawa | [[Category: Kigawa T]] | ||
[[Category: Koshiba | [[Category: Koshiba S]] | ||
[[Category: Li | [[Category: Li H]] | ||
[[Category: Sato M]] | |||
[[Category: Sato | [[Category: Tochio N]] | ||
[[Category: Tochio | [[Category: Tomizawa T]] | ||
[[Category: Tomizawa | [[Category: Watanabe S]] | ||
[[Category: Watanabe | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | |||
Latest revision as of 21:50, 29 May 2024
Solution structure of the chromo domain of Mortality factor 4-like protein 1 from humanSolution structure of the chromo domain of Mortality factor 4-like protein 1 from human
Structural highlights
FunctionMO4L1_HUMAN Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.[1] [2] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References
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