1sij: Difference between revisions

Revision as of 08:44, 3 May 2008

Crystal structure of the Aldehyde Dehydrogenase (a.k.a. AOR or MOP) of Desulfovibrio gigas covalently bound to [AsO3]-

OverviewOverview

X-ray crystallography has been used to determine the structure of arsenite-inhibited aldehyde dehydrogenase from Desulfovibrio gigas, a member of the xanthine oxidase family of mononuclear molybdenum enzymes. The structure shows an AsO3 moiety bound to the molybdenum atom of the active site through one of the oxygen atoms. A reduced sample of arsenite-inhibited aldehyde dehydrogenase has a Mo(V) signal that shows anisotropic hyperfine and quadrupole coupling to one arsenic atom. This signal has a strong resemblance with a previously reported signal for arsenite-inhibited xanthine oxidase.

About this StructureAbout this Structure

1SIJ is a Single protein structure of sequence from Desulfovibrio gigas. Full crystallographic information is available from OCA.

ReferenceReference

X-ray crystal structure and EPR spectra of "arsenite-inhibited" Desulfovibriogigas aldehyde dehydrogenase: a member of the xanthine oxidase family., Boer DR, Thapper A, Brondino CD, Romao MJ, Moura JJ, J Am Chem Soc. 2004 Jul 21;126(28):8614-5. PMID:15250689 Page seeded by OCA on Sat May 3 08:44:47 2008

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OCA

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 [[Image:1sij.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1sij |SIZE=350|CAPTION= <scene name='initialview01'>1sij</scene>, resolution 2.30&Aring;
+The line below this paragraph, containing "STRUCTURE_1sij", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=AST:ARSENITE'>AST</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PCD:(MOLYBDOPTERIN-CYTOSINE+DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V)'>PCD</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_oxidase Aldehyde oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.3.1 1.2.3.1] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1sij|  PDB=1sij  |  SCENE=  }}
-|RELATEDENTRY=[[1hlr|1HLR]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sij OCA], [http://www.ebi.ac.uk/pdbsum/1sij PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sij RCSB]</span>
-}}
 '''Crystal structure of the Aldehyde Dehydrogenase (a.k.a. AOR or MOP) of Desulfovibrio gigas covalently bound to [AsO3]-'''
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 [[Category: Romao, M J.]]
 [[Category: Thapper, A.]]
-[[Category: aldehyde oxidoreductase]]
+[[Category: Aldehyde oxidoreductase]]
-[[Category: arsenite inhibition]]
+[[Category: Arsenite inhibition]]
-[[Category: xanthine oxidase family]]
+[[Category: Xanthine oxidase family]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:44:47 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:42:31 2008''