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==Solution structure of three tandem repeats of zf-C2H2 domains from human Kruppel-like factor 5== | ==Solution structure of three tandem repeats of zf-C2H2 domains from human Kruppel-like factor 5== | ||
<StructureSection load='2ebt' size='340' side='right'caption='[[2ebt | <StructureSection load='2ebt' size='340' side='right'caption='[[2ebt]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ebt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2ebt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The April 2009 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Oct and Sox Transcription Factors'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2009_4 10.2210/rcsb_pdb/mom_2009_4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EBT FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ebt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ebt OCA], [https://pdbe.org/2ebt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ebt RCSB], [https://www.ebi.ac.uk/pdbsum/2ebt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ebt ProSAT], [https://www.topsan.org/Proteins/RSGI/2ebt TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ebt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ebt OCA], [https://pdbe.org/2ebt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ebt RCSB], [https://www.ebi.ac.uk/pdbsum/2ebt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ebt ProSAT], [https://www.topsan.org/Proteins/RSGI/2ebt TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/KLF5_HUMAN KLF5_HUMAN] Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Oct and Sox Transcription Factors]] | [[Category: Oct and Sox Transcription Factors]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Hayashi | [[Category: Hayashi F]] | ||
[[Category: Nagashima | [[Category: Nagashima T]] | ||
[[Category: Yokoyama S]] | |||
[[Category: Yokoyama | |||