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==Cryo-EM structure of Thogoto virus polymerase in transcription initiation conformation 2== | |||
<StructureSection load='8z90' size='340' side='right'caption='[[8z90]], [[Resolution|resolution]] 2.87Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8z90]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Thogoto_virus_(isolate_SiAr_126) Thogoto virus (isolate SiAr 126)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Z90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Z90 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.87Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G2P:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>G2P</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8z90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8z90 OCA], [https://pdbe.org/8z90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8z90 RCSB], [https://www.ebi.ac.uk/pdbsum/8z90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8z90 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PA_THOGV PA_THOGV] Initiates transcription by a unique cap-stealing mechanism that involves the cleavage of only the m(7)GpppAm structure from cellular hnRNAs. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Chang T]] | |||
[[Category: Chen X]] | |||
[[Category: Xiong X]] | |||
[[Category: Xue L]] | |||
Latest revision as of 21:10, 29 May 2024
Cryo-EM structure of Thogoto virus polymerase in transcription initiation conformation 2Cryo-EM structure of Thogoto virus polymerase in transcription initiation conformation 2
Structural highlights
FunctionPA_THOGV Initiates transcription by a unique cap-stealing mechanism that involves the cleavage of only the m(7)GpppAm structure from cellular hnRNAs. |
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