8pkm: Difference between revisions

Latest revision as of 21:03, 29 May 2024

Befiradol-bound serotonin 5-HT1A receptor - Gi Protein ComplexBefiradol-bound serotonin 5-HT1A receptor - Gi Protein Complex

Structural highlights

8pkm is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.9Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GNAI1_HUMAN Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.^[1] ^[2]

References

↑ Cho H, Kehrl JH. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. J Cell Biol. 2007 Jul 16;178(2):245-55. PMID:17635935 doi:10.1083/jcb.200604114
↑ Johnston CA, Siderovski DP. Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2001-6. Epub 2007 Jan 30. PMID:17264214

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OCA

[1] Cho H, Kehrl JH. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. J Cell Biol. 2007 Jul 16;178(2):245-55. PMID:17635935 doi:10.1083/jcb.200604114

[2] Johnston CA, Siderovski DP. Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2001-6. Epub 2007 Jan 30. PMID:17264214

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8pkm is ON HOLD  until Paper Publication
+==Befiradol-bound serotonin 5-HT1A receptor - Gi Protein Complex==
+<StructureSection load='8pkm' size='340' side='right'caption='[[8pkm]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-Authors: Schneider, J., Gmeiner, P., Hove, T.T., Rasmussen, T., Boettcher, B.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8pkm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PKM FirstGlance]. <br>
-Description: Befiradol-bound serotonin 5-HT1A receptor -Gi Protein Complex
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=T7M:(2R)-1-(HEPTADECANOYLOXY)-3-{[(R)-HYDROXY{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-TETRAHYDROXY-4-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPAN-2-YL+(5Z,8Z,11Z,14Z)-ICOSA-5,8,11,14-TETRAENOATE'>T7M</scene>, <scene name='pdbligand=ZKV:(3-chloranyl-4-fluoranyl-phenyl)-[4-fluoranyl-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone'>ZKV</scene></td></tr>
-[[Category: Boettcher, B]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pkm OCA], [https://pdbe.org/8pkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pkm RCSB], [https://www.ebi.ac.uk/pdbsum/8pkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pkm ProSAT]</span></td></tr>
-[[Category: Gmeiner, P]]
+</table>
-[[Category: Rasmussen, T]]
+== Function ==
-[[Category: Schneider, J]]
+[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
-[[Category: Hove, T.T]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Boettcher B]]
+[[Category: Gmeiner P]]
+[[Category: Hove TT]]
+[[Category: Rasmussen T]]
+[[Category: Schneider J]]

8pkm: Difference between revisions

Latest revision as of 21:03, 29 May 2024

Befiradol-bound serotonin 5-HT1A receptor - Gi Protein ComplexBefiradol-bound serotonin 5-HT1A receptor - Gi Protein Complex

Structural highlights

Function

References

Contents

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8pkm: Difference between revisions

Latest revision as of 21:03, 29 May 2024

Befiradol-bound serotonin 5-HT1A receptor - Gi Protein ComplexBefiradol-bound serotonin 5-HT1A receptor - Gi Protein Complex

Structural highlights

Function

References

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