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'''CRYSTAL STRUCTURE OF A SRC-HOMOLOGY 3 (SH3) DOMAIN''' | '''CRYSTAL STRUCTURE OF A SRC-HOMOLOGY 3 (SH3) DOMAIN''' | ||
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[[Category: Saraste, M.]] | [[Category: Saraste, M.]] | ||
[[Category: Wierenga, R K.]] | [[Category: Wierenga, R K.]] | ||
[[Category: | [[Category: Cytoskeleton]] | ||
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Revision as of 08:42, 3 May 2008
CRYSTAL STRUCTURE OF A SRC-HOMOLOGY 3 (SH3) DOMAIN
OverviewOverview
The Src-homologous SH3 domain is a small domain present in a large number of proteins that are involved in signal transduction, such as the Src protein tyrosine kinase, or in membrane-cytoskeleton interactions, but the function of SH3 is still unknown (reviewed in refs 1-3). Here we report the three-dimensional structure at 1.8 A resolution of the SH3 domain of the cytoskeletal protein spectrin expressed in Escherichia coli. The domain is a compact beta-barrel made of five antiparallel beta-strands. The amino acids that are conserved in the SH3 sequences are located close to each other on one side of the molecule. This surface is rich in aromatic and carboxylic amino acids, and is distal to the region of the molecule where the N and C termini reside and where SH3 inserts into the alpha-spectrin chain. We suggest that a protein ligand binds to this conserved surface of SH3.
About this StructureAbout this Structure
1SHG is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of a Src-homology 3 (SH3) domain., Musacchio A, Noble M, Pauptit R, Wierenga R, Saraste M, Nature. 1992 Oct 29;359(6398):851-5. PMID:1279434 Page seeded by OCA on Sat May 3 08:42:37 2008