Alpha-glucosidase: Difference between revisions
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'''Alpha glucosidase''' (AGS) or '''maltase''' breaks down the 1,4-α bonds in starch or disaccharides to produce glucose. '''Maltase''' breaks down maltose. '''Isomaltase''' or '''sucrase-isomaltase''' or '''oligo-1,6-glucosidase''' breaks the 1,6 bond.<ref>PMID:18848471</ref> | '''Alpha glucosidase''' (AGS) or '''maltase''' breaks down the 1,4-α bonds in starch or disaccharides to produce glucose. '''Maltase''' breaks down maltose. '''Isomaltase''' or '''sucrase-isomaltase''' or '''oligo-1,6-glucosidase''' breaks the 1,6 bond.<ref>PMID:18848471</ref> | ||
*Maltase-glucoamylase has important role in glucose production. It hydrolize linear alpha-1,4-linked oligosaccharides<ref>PMID:22058037</ref>. | *'''Maltase-glucoamylase''' has important role in glucose production. It hydrolize linear alpha-1,4-linked oligosaccharides<ref>PMID:22058037</ref>.<br /> | ||
*'''Acid-alpha gucosidase''' degrades glycogen polymers to glucose in the acidic lysosomes<ref>PMID:17217857</ref>.<br /> | |||
For details see [[Sucrase-isomaltase]]. | For details see [[Sucrase-isomaltase]]. | ||
Revision as of 11:45, 23 May 2024
FunctionAlpha glucosidase (AGS) or maltase breaks down the 1,4-α bonds in starch or disaccharides to produce glucose. Maltase breaks down maltose. Isomaltase or sucrase-isomaltase or oligo-1,6-glucosidase breaks the 1,6 bond.[1]
For details see Sucrase-isomaltase. See also Kennedy research and Carbohydrate Metabolism. DiseaseAGS deficiency is the cause of Pompe Disease. AGS inhibitors are used as anti-diabetic drugs and can potentially prevent the fusion of HIV and hepatitis B virus to cells. Structural highlights(PDB code 3a4a).[4] Water molecules shown as red spheres. . 3D structures of α-glucosidaseAlpha-glucosidase 3D structures
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ReferencesReferences
- ↑ Gloster TM, Turkenburg JP, Potts JR, Henrissat B, Davies GJ. Divergence of catalytic mechanism within a glycosidase family provides insight into evolution of carbohydrate metabolism by human gut flora. Chem Biol. 2008 Oct 20;15(10):1058-67. Epub 2008 Oct 9. PMID:18848471 doi:10.1016/j.chembiol.2008.09.005
- ↑ Ren L, Qin X, Cao X, Wang L, Bai F, Bai G, Shen Y. Structural insight into substrate specificity of human intestinal maltase-glucoamylase. Protein Cell. 2011 Oct;2(10):827-36. Epub 2011 Nov 6. PMID:22058037 doi:10.1007/s13238-011-1105-3
- ↑ Fukuda T, Roberts A, Plotz PH, Raben N. Acid alpha-glucosidase deficiency (Pompe disease). Curr Neurol Neurosci Rep. 2007 Jan;7(1):71-7. PMID:17217857 doi:10.1007/s11910-007-0024-4
- ↑ Yamamoto K, Miyake H, Kusunoki M, Osaki S. Crystal structures of isomaltase from Saccharomyces cerevisiae and in complex with its competitive inhibitor maltose. FEBS J. 2010 Oct;277(20):4205-14. doi: 10.1111/j.1742-4658.2010.07810.x., Epub 2010 Aug 31. PMID:20812985 doi:10.1111/j.1742-4658.2010.07810.x