2azx: Difference between revisions
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<StructureSection load='2azx' size='340' side='right'caption='[[2azx]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='2azx' size='340' side='right'caption='[[2azx]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2azx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2azx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AZX FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2azx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azx OCA], [https://pdbe.org/2azx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2azx RCSB], [https://www.ebi.ac.uk/pdbsum/2azx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2azx ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2azx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azx OCA], [https://pdbe.org/2azx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2azx RCSB], [https://www.ebi.ac.uk/pdbsum/2azx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2azx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/SYWC_HUMAN SYWC_HUMAN] Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.<ref>PMID:11773626</ref> <ref>PMID:1373391</ref> <ref>PMID:11773625</ref> <ref>PMID:14630953</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Bos taurus]] | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ewalt KL]] | |||
[[Category: Ewalt | [[Category: Kohrer C]] | ||
[[Category: Kohrer | [[Category: Liu J]] | ||
[[Category: Liu | [[Category: McRee DE]] | ||
[[Category: McRee | [[Category: Otero FJ]] | ||
[[Category: Otero | [[Category: RajBhandary UL]] | ||
[[Category: RajBhandary | [[Category: Schimmel P]] | ||
[[Category: Schimmel | [[Category: Skene RJ]] | ||
[[Category: Skene | [[Category: Swairjo MA]] | ||
[[Category: Swairjo | [[Category: Yang XL]] | ||
[[Category: Yang | |||