6sky: Difference between revisions

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<SX load='6sky' size='340' side='right' viewer='molstar' caption='[[6sky]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<SX load='6sky' size='340' side='right' viewer='molstar' caption='[[6sky]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6sky]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SKY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SKY FirstGlance]. <br>
<table><tr><td colspan='2'>[[6sky]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SKY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sky OCA], [http://pdbe.org/6sky PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sky RCSB], [http://www.ebi.ac.uk/pdbsum/6sky PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sky ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sky OCA], [https://pdbe.org/6sky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sky RCSB], [https://www.ebi.ac.uk/pdbsum/6sky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sky ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/G0S4S9_CHATD G0S4S9_CHATD]] Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.[RuleBase:RU365027]  
[https://www.uniprot.org/uniprot/G0S4S9_CHATD G0S4S9_CHATD] Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.[RuleBase:RU365027]
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Chatd]]
[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Eustermann SE]]
[[Category: Eustermann, S E]]
[[Category: Hopfner KP]]
[[Category: Hopfner, K P]]
[[Category: Jansma M]]
[[Category: Jansma, M]]
[[Category: Kostrewa D]]
[[Category: Kostrewa, D]]
[[Category: Lammens K]]
[[Category: Lammens, K]]
[[Category: Alpha solenoid]]
[[Category: Atm]]
[[Category: Dimer]]
[[Category: Dna damage signaling]]
[[Category: Kinase]]
[[Category: Nucleus]]
[[Category: Pikk]]
[[Category: Tranferase]]
[[Category: Transferase]]

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