6ehm: Difference between revisions

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<SX load='6ehm' size='340' side='right' viewer='molstar' caption='[[6ehm]], [[Resolution|resolution]] 7.30&Aring;' scene=''>
<SX load='6ehm' size='340' side='right' viewer='molstar' caption='[[6ehm]], [[Resolution|resolution]] 7.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6ehm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebov-may Ebov-may]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EHM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6EHM FirstGlance]. <br>
<table><tr><td colspan='2'>[[6ehm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_-_Mayinga,_Zaire,_1976 Ebola virus - Mayinga, Zaire, 1976]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EHM FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=128952 EBOV-May]), VP24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=128952 EBOV-May])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ehm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ehm OCA], [http://pdbe.org/6ehm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ehm RCSB], [http://www.ebi.ac.uk/pdbsum/6ehm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ehm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ehm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ehm OCA], [https://pdbe.org/6ehm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ehm RCSB], [https://www.ebi.ac.uk/pdbsum/6ehm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ehm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NCAP_EBOZM NCAP_EBOZM]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases. [[http://www.uniprot.org/uniprot/VP24_EBOZM VP24_EBOZM]] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.<ref>PMID:12191476</ref> <ref>PMID:12525613</ref> <ref>PMID:15220407</ref> <ref>PMID:17928350</ref> 
[https://www.uniprot.org/uniprot/NCAP_EBOZM NCAP_EBOZM] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases.
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
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[[Category: Ebov-may]]
[[Category: Ebola virus - Mayinga, Zaire, 1976]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Becker, S]]
[[Category: Becker S]]
[[Category: Briggs, J A.G]]
[[Category: Briggs JAG]]
[[Category: Clarke, M]]
[[Category: Clarke M]]
[[Category: Koehler, A]]
[[Category: Koehler A]]
[[Category: Kolesnikova, L]]
[[Category: Kolesnikova L]]
[[Category: Noda, T]]
[[Category: Noda T]]
[[Category: Wan, W]]
[[Category: Wan W]]
[[Category: Nucleocapsid]]
[[Category: Virus like particle]]
[[Category: Virus-like particle]]

Latest revision as of 13:08, 22 May 2024

Model of the Ebola virus nucleocapsid subunit from recombinant virus-like particlesModel of the Ebola virus nucleocapsid subunit from recombinant virus-like particles

6ehm, resolution 7.30Å

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