8rm5: Difference between revisions

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-'''Unreleased structure'''
-The entry 8rm5 is ON HOLD  until Paper Publication
+==Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex==
+<StructureSection load='8rm5' size='340' side='right'caption='[[8rm5]], [[Resolution|resolution]] 6.90&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8rm5]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RM5 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.9&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rm5 OCA], [https://pdbe.org/8rm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rm5 RCSB], [https://www.ebi.ac.uk/pdbsum/8rm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rm5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/LSM6_HUMAN LSM6_HUMAN] Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Dybkov O]]
+[[Category: Kastner B]]
+[[Category: Kumar V]]
+[[Category: Ludwig S]]
+[[Category: Luehrmann R]]
+[[Category: Stark H]]
+[[Category: Urlaub H]]
+[[Category: Will CL]]
+[[Category: Zhang Z]]
+[[Category: Zhong J]]