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==Cryo-EM structure of the cross-exon pre-B+AMPPNP complex== | |||
<StructureSection load='8r08' size='340' side='right'caption='[[8r08]], [[Resolution|resolution]] 6.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8r08]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8R08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8R08 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.1Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8r08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8r08 OCA], [https://pdbe.org/8r08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8r08 RCSB], [https://www.ebi.ac.uk/pdbsum/8r08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8r08 ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/U5S1_HUMAN U5S1_HUMAN] Mandibulofacial dysostosis-microcephaly syndrome. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/U5S1_HUMAN U5S1_HUMAN] Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Dybkov O]] | |||
[[Category: Kastner B]] | |||
[[Category: Kumar V]] | |||
[[Category: Ludwig S]] | |||
[[Category: Luehrmann R]] | |||
[[Category: Stark H]] | |||
[[Category: Urlaub H]] | |||
[[Category: Will CL]] | |||
[[Category: Zhang Z]] | |||
[[Category: Zhong J]] | |||
Revision as of 11:04, 22 May 2024
Cryo-EM structure of the cross-exon pre-B+AMPPNP complexCryo-EM structure of the cross-exon pre-B+AMPPNP complex
Structural highlights
DiseaseU5S1_HUMAN Mandibulofacial dysostosis-microcephaly syndrome. The disease is caused by mutations affecting the gene represented in this entry. FunctionU5S1_HUMAN Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP. |
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