1xqs: Difference between revisions
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<StructureSection load='1xqs' size='340' side='right'caption='[[1xqs]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='1xqs' size='340' side='right'caption='[[1xqs]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1xqs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1xqs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XQS FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqs OCA], [https://pdbe.org/1xqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xqs RCSB], [https://www.ebi.ac.uk/pdbsum/1xqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xqs ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqs OCA], [https://pdbe.org/1xqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xqs RCSB], [https://www.ebi.ac.uk/pdbsum/1xqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xqs ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/HPBP1_HUMAN HPBP1_HUMAN] Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.<ref>PMID:9830037</ref> <ref>PMID:10786638</ref> <ref>PMID:12651857</ref> <ref>PMID:15215316</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bracher | [[Category: Bracher A]] | ||
[[Category: Brodsky | [[Category: Brodsky JL]] | ||
[[Category: Chang | [[Category: Chang HC]] | ||
[[Category: Dragovic | [[Category: Dragovic Z]] | ||
[[Category: Guerriero | [[Category: Guerriero V]] | ||
[[Category: Hartl | [[Category: Hartl FU]] | ||
[[Category: Shomura | [[Category: Shomura Y]] | ||
[[Category: Tzvetkov | [[Category: Tzvetkov N]] | ||
[[Category: Young | [[Category: Young JC]] | ||