1wjl: Difference between revisions

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==Solution structure of PDZ domain of mouse Cypher protein==
==Solution structure of PDZ domain of mouse Cypher protein==
<StructureSection load='1wjl' size='340' side='right'caption='[[1wjl]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1wjl' size='340' side='right'caption='[[1wjl]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1wjl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WJL FirstGlance]. <br>
<table><tr><td colspan='2'>[[1wjl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WJL FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN cDNA 1110032B18 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wjl OCA], [https://pdbe.org/1wjl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wjl RCSB], [https://www.ebi.ac.uk/pdbsum/1wjl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wjl ProSAT], [https://www.topsan.org/Proteins/RSGI/1wjl TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wjl OCA], [https://pdbe.org/1wjl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wjl RCSB], [https://www.ebi.ac.uk/pdbsum/1wjl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wjl ProSAT], [https://www.topsan.org/Proteins/RSGI/1wjl TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/LDB3_MOUSE LDB3_MOUSE]] May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.<ref>PMID:10391924</ref>
[https://www.uniprot.org/uniprot/LDB3_MOUSE LDB3_MOUSE] May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.<ref>PMID:10391924</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Inoue, M]]
[[Category: Inoue M]]
[[Category: Kigawa, T]]
[[Category: Kigawa T]]
[[Category: Koshiba, S]]
[[Category: Koshiba S]]
[[Category: Structural genomic]]
[[Category: Sato M]]
[[Category: Sato, M]]
[[Category: Tochio N]]
[[Category: Tochio, N]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: A striated muscle-specific pdzlim domain]]
[[Category: Lim domain binding 3]]
[[Category: Pdz domain]]
[[Category: Protein binding]]
[[Category: Rsgi]]
[[Category: Signal transduction]]
[[Category: Z-band alternatively spliced pdz-motif protein]]
[[Category: Zasp]]

Latest revision as of 16:43, 9 May 2024

Solution structure of PDZ domain of mouse Cypher proteinSolution structure of PDZ domain of mouse Cypher protein

Structural highlights

1wjl is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

LDB3_MOUSE May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Zhou Q, Ruiz-Lozano P, Martone ME, Chen J. Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C. J Biol Chem. 1999 Jul 9;274(28):19807-13. PMID:10391924
Drag the structure with the mouse to rotate

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