1s1s: Difference between revisions

Revision as of 08:11, 3 May 2008

Crystal Structure of ZipA in complex with indoloquinolizin 10b

OverviewOverview

The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ binding. The X-ray crystal structure of one of these molecules complexed with ZipA was solved. The structure revealed an unexpected binding mode, facilitated by desolvation of a loosely bound surface water.

About this StructureAbout this Structure

1S1S is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction., Jennings LD, Foreman KW, Rush TS 3rd, Tsao DH, Mosyak L, Li Y, Sukhdeo MN, Ding W, Dushin EG, Kenny CH, Moghazeh SL, Petersen PJ, Ruzin AV, Tuckman M, Sutherland AG, Bioorg Med Chem Lett. 2004 Mar 22;14(6):1427-31. PMID:15006376 Page seeded by OCA on Sat May 3 08:11:30 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1s1s.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1s1s |SIZE=350|CAPTION= <scene name='initialview01'>1s1s</scene>, resolution 2.10&Aring;
+The line below this paragraph, containing "STRUCTURE_1s1s", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=WAC:N-{3-[(7AR,12AS,12BS)-7-OXO-1,3,4,6,7,7A,12A,12B-OCTAHYDROINDOLO[2,3-A]QUINOLIZIN-12(2H)-YL]PROPYL}PROPANE-2-SULFONAMIDE'>WAC</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= ZIPA, B2412 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
+-->
-|DOMAIN=
+{{STRUCTURE_1s1s|  PDB=1s1s  |  SCENE=  }}
-|RELATEDENTRY=[[1s1j|1S1J]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1s OCA], [http://www.ebi.ac.uk/pdbsum/1s1s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s1s RCSB]</span>
-}}
 '''Crystal Structure of ZipA in complex with indoloquinolizin 10b'''
@@ Line 40: / Line 37: @@
 [[Category: Tsao, D H.]]
 [[Category: Tuckman, M.]]
-[[Category: cell cycle]]
+[[Category: Cell cycle]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:11:30 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:36:07 2008''