1rzk: Difference between revisions

Revision as of 08:06, 3 May 2008

HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B

OverviewOverview

The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.

About this StructureAbout this Structure

1RZK is a Single protein structure of sequence from Homo sapiens and Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120., Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:14981267 Page seeded by OCA on Sat May 3 08:06:28 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1rzk.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1rzk |SIZE=350|CAPTION= <scene name='initialview01'>1rzk</scene>, resolution 2.90&Aring;
+The line below this paragraph, containing "STRUCTURE_1rzk", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1rzk|  PDB=1rzk  |  SCENE=  }}
-|RELATEDENTRY=[[1g9n|1G9N]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rzk OCA], [http://www.ebi.ac.uk/pdbsum/1rzk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rzk RCSB]</span>
-}}
 '''HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B'''
@@ Line 40: / Line 37: @@
 [[Category: Wyatt, R.]]
 [[Category: Zhang, M Y.]]
-[[Category: antigen-binding fragment of human immunoglobulin 17b]]
+[[Category: Antigen-binding fragment of human immunoglobulin 17b]]
-[[Category: complex (hiv envelope protein/cd4/fab)]]
+[[Category: Hiv-1 exterior envelope gp120 from laboratory-adapted isolate]]
-[[Category: hiv-1 exterior envelope gp120 from laboratory-adapted isolate]]
+[[Category: Hxbc2]]
-[[Category: hxbc2]]
+[[Category: Surface t-cell glycoprotein cd4]]
-[[Category: surface t-cell glycoprotein cd4]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:06:28 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:35:13 2008''