2vgq: Difference between revisions

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 <StructureSection load='2vgq' size='340' side='right'caption='[[2vgq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2vgq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VGQ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2vgq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VGQ FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mh3|1mh3]], [[1hsj|1hsj]], [[1y4c|1y4c]], [[1ezo|1ezo]], [[1fqc|1fqc]], [[1anf|1anf]], [[1lls|1lls]], [[3mbp|3mbp]], [[1zkb|1zkb]], [[1mpb|1mpb]], [[1dmb|1dmb]], [[1ezp|1ezp]], [[1ez9|1ez9]], [[1zjl|1zjl]], [[2h25|2h25]], [[1jvx|1jvx]], [[1n3x|1n3x]], [[1nl5|1nl5]], [[1a7l|1a7l]], [[1r6z|1r6z]], [[1zmg|1zmg]], [[1t0k|1t0k]], [[1mh4|1mh4]], [[1jw5|1jw5]], [[1fqa|1fqa]], [[1iud|1iud]], [[1ziu|1ziu]], [[1mg1|1mg1]], [[1mdp|1mdp]], [[1fqb|1fqb]], [[1jw4|1jw4]], [[1omp|1omp]], [[1n3w|1n3w]], [[1nmu|1nmu]], [[1mpd|1mpd]], [[1ytv|1ytv]], [[1mdq|1mdq]], [[1lax|1lax]], [[1peb|1peb]], [[1mpc|1mpc]], [[1jvy|1jvy]], [[1fqd|1fqd]], [[1svx|1svx]], [[2d21|2d21]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900010:alpha-maltotetraose'>PRD_900010</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAVS, IPS1, KIAA1271, VISA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vgq OCA], [https://pdbe.org/2vgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vgq RCSB], [https://www.ebi.ac.uk/pdbsum/2vgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vgq ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/MAVS_HUMAN MAVS_HUMAN] Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.<ref>PMID:16125763</ref> <ref>PMID:16153868</ref> <ref>PMID:16177806</ref> <ref>PMID:16127453</ref> <ref>PMID:19631370</ref> <ref>PMID:20451243</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Escherichia coli]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Potter, J A]]
+[[Category: Potter JA]]
-[[Category: Randall, R E]]
+[[Category: Randall RE]]
-[[Category: Taylor, G L]]
+[[Category: Taylor GL]]
-[[Category: Caspase activation]]
-[[Category: Caspase recruitment domain]]
-[[Category: Chimera]]
-[[Category: Fusion protein]]
-[[Category: Immune system]]
-[[Category: Immune system-transport complex]]
-[[Category: Immune system/transport]]
-[[Category: Innate immunity]]
-[[Category: Ips1/mavs/visa/cardif]]
-[[Category: Sugar transport]]
-[[Category: Transport]]