2ccu: Difference between revisions
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<StructureSection load='2ccu' size='340' side='right'caption='[[2ccu]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='2ccu' size='340' side='right'caption='[[2ccu]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ccu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2ccu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CCU FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2D9:4-CHLORO-6-(4-{4-[4-(METHYLSULFONYL)BENZYL]PIPERAZIN-1-YL}-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL'>2D9</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ccu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ccu OCA], [https://pdbe.org/2ccu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ccu RCSB], [https://www.ebi.ac.uk/pdbsum/2ccu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ccu ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ccu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ccu OCA], [https://pdbe.org/2ccu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ccu RCSB], [https://www.ebi.ac.uk/pdbsum/2ccu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ccu ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Barril | [[Category: Barril X]] | ||
[[Category: Beswick | [[Category: Beswick MC]] | ||
[[Category: Collier | [[Category: Collier A]] | ||
[[Category: Drysdale | [[Category: Drysdale MJ]] | ||
[[Category: Dymock | [[Category: Dymock BW]] | ||
[[Category: Fink | [[Category: Fink A]] | ||
[[Category: Grant | [[Category: Grant K]] | ||
[[Category: Howes | [[Category: Howes R]] | ||
[[Category: Jordan | [[Category: Jordan AM]] | ||
[[Category: Massey | [[Category: Massey A]] | ||
[[Category: Surgenor | [[Category: Surgenor A]] | ||
[[Category: Wayne | [[Category: Wayne J]] | ||
[[Category: Workman | [[Category: Workman P]] | ||
[[Category: Wright | [[Category: Wright L]] | ||