2bry: Difference between revisions
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<StructureSection load='2bry' size='340' side='right'caption='[[2bry]], [[Resolution|resolution]] 1.45Å' scene=''> | <StructureSection load='2bry' size='340' side='right'caption='[[2bry]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2bry]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2bry]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BRY FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bry OCA], [https://pdbe.org/2bry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bry RCSB], [https://www.ebi.ac.uk/pdbsum/2bry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bry ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bry OCA], [https://pdbe.org/2bry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bry RCSB], [https://www.ebi.ac.uk/pdbsum/2bry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bry ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/MICA1_MOUSE MICA1_MOUSE] Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments (By similarity). Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Berrow | [[Category: Berrow N]] | ||
[[Category: Harlos | [[Category: Harlos K]] | ||
[[Category: Jones | [[Category: Jones EY]] | ||
[[Category: Kolodkin | [[Category: Kolodkin AL]] | ||
[[Category: Owens | [[Category: Owens RJ]] | ||
[[Category: Pasterkamp | [[Category: Pasterkamp RJ]] | ||
[[Category: Siebold | [[Category: Siebold C]] | ||
[[Category: Stuart | [[Category: Stuart DI]] | ||
[[Category: Terman | [[Category: Terman JR]] | ||
[[Category: Walter | [[Category: Walter TS]] | ||