2blb: Difference between revisions

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OCA

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 <StructureSection load='2blb' size='340' side='right'caption='[[2blb]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2blb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BLB FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2blb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BLB FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CP7:6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE'>CP7</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bl9|2bl9]], [[2bla|2bla]], [[2blc|2blc]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CP7:6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE'>CP7</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2blb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2blb OCA], [https://pdbe.org/2blb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2blb RCSB], [https://www.ebi.ac.uk/pdbsum/2blb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2blb ProSAT], [https://www.topsan.org/Proteins/RSGI/2blb TOPSAN]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/DRTS_PLAVI DRTS_PLAVI] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 35: / Line 36: @@
 __TOC__
 </StructureSection>
-[[Category: Dihydrofolate reductase]]
 [[Category: Large Structures]]
-[[Category: Chitnumsub, P]]
+[[Category: Plasmodium vivax]]
-[[Category: Khongsuk, P]]
+[[Category: Chitnumsub P]]
-[[Category: Kongsaeree, P]]
+[[Category: Khongsuk P]]
-[[Category: Leartsakulpanich, U]]
+[[Category: Kongsaeree P]]
-[[Category: Tarnchompoo, B]]
+[[Category: Leartsakulpanich U]]
-[[Category: Walkinshaw, M D]]
+[[Category: Tarnchompoo B]]
-[[Category: Yuthavong, Y]]
+[[Category: Walkinshaw MD]]
-[[Category: Drug resistance]]
+[[Category: Yuthavong Y]]
-[[Category: Malaria]]
-[[Category: Oxidoreductase]]
-[[Category: Plamodium vivax]]
-[[Category: Pyrimethamine]]