2bge: Difference between revisions
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<StructureSection load='2bge' size='340' side='right'caption='[[2bge]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='2bge' size='340' side='right'caption='[[2bge]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2bge]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2bge]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BGE FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T2D:1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE'>T2D</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bge OCA], [https://pdbe.org/2bge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bge RCSB], [https://www.ebi.ac.uk/pdbsum/2bge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bge ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bge OCA], [https://pdbe.org/2bge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bge RCSB], [https://www.ebi.ac.uk/pdbsum/2bge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bge ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Black E]] | |||
[[Category: Black | [[Category: Breed J]] | ||
[[Category: Breed | [[Category: Breeze AL]] | ||
[[Category: Breeze | [[Category: Embrey K]] | ||
[[Category: Embrey | [[Category: Garcia R]] | ||
[[Category: Garcia | [[Category: Gero TW]] | ||
[[Category: Gero | [[Category: Godfrey L]] | ||
[[Category: Godfrey | [[Category: Kenny PW]] | ||
[[Category: Kenny | [[Category: Minshull CA]] | ||
[[Category: Minshull | [[Category: Morley AD]] | ||
[[Category: Morley | [[Category: Pannifer AD]] | ||
[[Category: Pannifer | [[Category: Read J]] | ||
[[Category: Read | [[Category: Rees A]] | ||
[[Category: Rees | [[Category: Russell DJ]] | ||
[[Category: Russell | [[Category: Toader D]] | ||
[[Category: Toader | [[Category: Tucker J]] | ||
[[Category: Tucker | |||
Latest revision as of 12:15, 9 May 2024
Structure-based design of Protein Tyrosine Phosphatase-1B InhibitorsStructure-based design of Protein Tyrosine Phosphatase-1B Inhibitors
Structural highlights
FunctionPTN1_HUMAN Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.[1] [2] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedUsing structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template. Structure-based design of protein tyrosine phosphatase-1B inhibitors.,Black E, Breed J, Breeze AL, Embrey K, Garcia R, Gero TW, Godfrey L, Kenny PW, Morley AD, Minshull CA, Pannifer AD, Read J, Rees A, Russell DJ, Toader D, Tucker J Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7. PMID:15863305[3] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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