1sy6: Difference between revisions

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<StructureSection load='1sy6' size='340' side='right'caption='[[1sy6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='1sy6' size='340' side='right'caption='[[1sy6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1sy6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SY6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1SY6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1sy6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SY6 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD3G, T3G, CD3E, T3E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1sy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sy6 OCA], [http://pdbe.org/1sy6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sy6 RCSB], [http://www.ebi.ac.uk/pdbsum/1sy6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sy6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sy6 OCA], [https://pdbe.org/1sy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sy6 RCSB], [https://www.ebi.ac.uk/pdbsum/1sy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sy6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CD3G_HUMAN CD3G_HUMAN]] The CD3 complex mediates signal transduction.  
[https://www.uniprot.org/uniprot/CD3E_HUMAN CD3E_HUMAN] The CD3 complex mediates signal transduction.[https://www.uniprot.org/uniprot/CD3G_HUMAN CD3G_HUMAN] The CD3 complex mediates signal transduction.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sy6 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sy6 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The CD3 epsilon gamma heterodimer is essential for expression and function of the T cell receptor. The crystal structure of the human CD3 epsilon gamma heterodimer is described to 2.1-A resolution complexed with OKT3, a therapeutic mAb that not only activates and tolerizes mature T cells but also induces regulatory T cells. The mode of CD3 epsilon gamma dimerization provides a general structural basis for CD3 assembly and maps candidate T cell antigen receptor docking sites, including a duplicated linear region rich in acidic residues that is unique to human CD3 epsilon. OKT3 binds to an atypically small area of CD3 epsilon and has a low affinity for the isolated CD3 epsilon gamma heterodimer. The structure of the OKT3/CD3 epsilon gamma complex has implications for T cell signaling and therapeutic design.
Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.,Kjer-Nielsen L, Dunstone MA, Kostenko L, Ely LK, Beddoe T, Mifsud NA, Purcell AW, Brooks AG, McCluskey J, Rossjohn J Proc Natl Acad Sci U S A. 2004 May 18;101(20):7675-80. Epub 2004 May 10. PMID:15136729<ref>PMID:15136729</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1sy6" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
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*[[CD3|CD3]]
*[[CD3|CD3]]
*[[CD3 3D structures|CD3 3D structures]]
*[[CD3 3D structures|CD3 3D structures]]
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Beddoe, T]]
[[Category: Beddoe T]]
[[Category: Brooks, A G]]
[[Category: Brooks AG]]
[[Category: Dunstone, M A]]
[[Category: Dunstone MA]]
[[Category: Ely, L K]]
[[Category: Ely LK]]
[[Category: Kjer-Nielsen, L]]
[[Category: Kjer-Nielsen L]]
[[Category: Kostenko, L]]
[[Category: Kostenko L]]
[[Category: McCluskey, J]]
[[Category: McCluskey J]]
[[Category: Misfud, N A]]
[[Category: Misfud NA]]
[[Category: Purcell, A W]]
[[Category: Purcell AW]]
[[Category: Rossjohn, J]]
[[Category: Rossjohn J]]
[[Category: Cd3 epsilon]]
[[Category: Cd3 gamma]]
[[Category: Okt3 fab]]
[[Category: Signaling protein-antibiotic complex]]

Revision as of 11:36, 1 May 2024

Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab FragmentCrystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment

Structural highlights

1sy6 is a 3 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CD3E_HUMAN The CD3 complex mediates signal transduction.CD3G_HUMAN The CD3 complex mediates signal transduction.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1sy6, resolution 2.10Å

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OCA
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