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==== | ==Cryo-EM structure of human apo RNA Polymerase III== | ||
<StructureSection load='7a6h' size='340' side='right'caption='[[7a6h]]' scene=''> | <StructureSection load='7a6h' size='340' side='right'caption='[[7a6h]], [[Resolution|resolution]] 3.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7a6h]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A6H FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a6h OCA], [https://pdbe.org/7a6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a6h RCSB], [https://www.ebi.ac.uk/pdbsum/7a6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a6h ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a6h OCA], [https://pdbe.org/7a6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a6h RCSB], [https://www.ebi.ac.uk/pdbsum/7a6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a6h ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/RPAC1_HUMAN RPAC1_HUMAN] Treacher-Collins syndrome;Hypomyelination-hypogonadotropic hypogonadism-hypodontia syndrome. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RPAC1_HUMAN RPAC1_HUMAN] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).[UniProtKB:P07703]<ref>PMID:26151409</ref> | |||
==See Also== | |||
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Girbig M]] | ||
[[Category: Misiaszek AD]] | |||
[[Category: Mueller CW]] | |||
[[Category: Vorlaender MK]] | |||
Latest revision as of 10:43, 1 May 2024
Cryo-EM structure of human apo RNA Polymerase IIICryo-EM structure of human apo RNA Polymerase III
Structural highlights
DiseaseRPAC1_HUMAN Treacher-Collins syndrome;Hypomyelination-hypogonadotropic hypogonadism-hypodontia syndrome. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. FunctionRPAC1_HUMAN DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).[UniProtKB:P07703][1] See AlsoReferences
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