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==The solution structure of PHS018 from pyrococcus horikoshii==
==The solution structure of PHS018 from pyrococcus horikoshii==
<StructureSection load='2glw' size='340' side='right'caption='[[2glw]], [[NMR_Ensembles_of_Models | 22 NMR models]]' scene=''>
<StructureSection load='2glw' size='340' side='right'caption='[[2glw]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2glw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GLW FirstGlance]. <br>
<table><tr><td colspan='2'>[[2glw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GLW FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PHS018 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=70601 Pyrococcus horikoshii])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2glw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2glw OCA], [https://pdbe.org/2glw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2glw RCSB], [https://www.ebi.ac.uk/pdbsum/2glw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2glw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2glw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2glw OCA], [https://pdbe.org/2glw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2glw RCSB], [https://www.ebi.ac.uk/pdbsum/2glw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2glw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O73971_PYRHO O73971_PYRHO]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2glw ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2glw ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The core of swapped-hairpin and double-psi beta barrels is formed by duplication of a conserved betaalphabeta element, suggesting a common evolutionary origin. The path connecting the two folds is unclear as the two barrels are not interconvertible by a simple topological modification, such as circular permutation. We have identified a protein family whose sequence properties are intermediate to the two folds. The structure of one of these proteins, Pyrococcus horikoshii PhS018, is also built by duplication of the conserved betaalphabeta element but shows yet a third topology, which we name the RIFT barrel. This topology is widespread in the structure database and spans three folds of the SCOP classification, including the middle domain of EF-Tu and the N domain of F1-ATPase. We propose that swapped-hairpin beta barrels arose from an ancestral RIFT barrel by strand invasion and double-psi beta barrels by a strand swap. We group the three barrel types into a metafold, the cradle-loop barrels.
Common evolutionary origin of swapped-hairpin and double-psi beta barrels.,Coles M, Hulko M, Djuranovic S, Truffault V, Koretke K, Martin J, Lupas AN Structure. 2006 Oct;14(10):1489-98. PMID:17027498<ref>PMID:17027498</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2glw" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pyrococcus horikoshii]]
[[Category: Pyrococcus horikoshii OT3]]
[[Category: Coles, M]]
[[Category: Coles M]]
[[Category: Hulko, M]]
[[Category: Hulko M]]
[[Category: Lupas, A N]]
[[Category: Lupas AN]]
[[Category: Martin, J]]
[[Category: Martin J]]
[[Category: Truffault, V]]
[[Category: Truffault V]]
[[Category: Bioinformatic]]
[[Category: Rift barrel]]
[[Category: Transcription]]

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