8ugy: Difference between revisions

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'''Unreleased structure'''


The entry 8ugy is ON HOLD  until Paper Publication
==Serotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with Mianserin==
 
<StructureSection load='8ugy' size='340' side='right'caption='[[8ugy]], [[Resolution|resolution]] 3.31&Aring;' scene=''>
Authors: Zilberg, G., Warren, A.L., Wacker, D.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8ugy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UGY FirstGlance]. <br>
Description: Serotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with Mianserin
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.31&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=WRU:Mianserin'>WRU</scene></td></tr>
[[Category: Wacker, D]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ugy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ugy OCA], [https://pdbe.org/8ugy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ugy RCSB], [https://www.ebi.ac.uk/pdbsum/8ugy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ugy ProSAT]</span></td></tr>
[[Category: Warren, A.L]]
</table>
[[Category: Zilberg, G]]
== Function ==
[https://www.uniprot.org/uniprot/5HT1E_HUMAN 5HT1E_HUMAN] G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.<ref>PMID:14744596</ref> <ref>PMID:1513320</ref> <ref>PMID:1608964</ref> <ref>PMID:1733778</ref> <ref>PMID:21422162</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Wacker D]]
[[Category: Warren AL]]
[[Category: Zilberg G]]

Revision as of 09:23, 1 May 2024

Serotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with MianserinSerotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with Mianserin

Structural highlights

8ugy is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.31Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

5HT1E_HUMAN G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.[1] [2] [3] [4] [5]

References

  1. ↑ Bai F, Yin T, Johnstone EM, Su C, Varga G, Little SP, Nelson DL. Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol. 2004 Jan 26;484(2-3):127-39. PMID:14744596 doi:10.1016/j.ejphar.2003.11.019
  2. ↑ Zgombick JM, Schechter LE, Macchi M, Hartig PR, Branchek TA, Weinshank RL. Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor. Mol Pharmacol. 1992 Aug;42(2):180-5 PMID:1513320
  3. ↑ McAllister G, Charlesworth A, Snodin C, Beer MS, Noble AJ, Middlemiss DN, Iversen LL, Whiting P. Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5517-21. PMID:1608964 doi:10.1073/pnas.89.12.5517
  4. ↑ Levy FO, Gudermann T, Birnbaumer M, Kaumann AJ, Birnbaumer L. Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase. FEBS Lett. 1992 Jan 20;296(2):201-6. PMID:1733778 doi:10.1016/0014-5793(92)80379-u
  5. ↑ Klein MT, Dukat M, Glennon RA, Teitler M. Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. J Pharmacol Exp Ther. 2011 Jun;337(3):860-7. PMID:21422162 doi:10.1124/jpet.111.179606

8ugy, resolution 3.31Å

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