8uh3: Difference between revisions

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'''Unreleased structure'''


The entry 8uh3 is ON HOLD  until Paper Publication
==Serotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with Setiptiline==
 
<StructureSection load='8uh3' size='340' side='right'caption='[[8uh3]], [[Resolution|resolution]] 3.31&Aring;' scene=''>
Authors: Wacker, D., Parpounas, A.K., Warren, A.L., Zilberg, G.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8uh3]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UH3 FirstGlance]. <br>
Description: Serotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with Setiptiline
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.31&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=WOQ:Setiptiline'>WOQ</scene></td></tr>
[[Category: Wacker, D]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uh3 OCA], [https://pdbe.org/8uh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uh3 RCSB], [https://www.ebi.ac.uk/pdbsum/8uh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uh3 ProSAT]</span></td></tr>
[[Category: Parpounas, A.K]]
</table>
[[Category: Warren, A.L]]
== Function ==
[[Category: Zilberg, G]]
[https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Parpounas AK]]
[[Category: Wacker D]]
[[Category: Warren AL]]
[[Category: Zilberg G]]

Revision as of 09:23, 1 May 2024

Serotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with SetiptilineSerotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with Setiptiline

Structural highlights

8uh3 is a 5 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.31Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GBB1_HUMAN Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.[1]

References

  1. ↑ Johnston CA, Kimple AJ, Giguere PM, Siderovski DP. Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2. Structure. 2008 Jul;16(7):1086-94. PMID:18611381 doi:http://dx.doi.org/10.1016/j.str.2008.04.010

8uh3, resolution 3.31Å

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OCA
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