8smp: Difference between revisions

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'''Unreleased structure'''


The entry 8smp is ON HOLD  until Paper Publication
==Xenopus laevis hyaluronan synthase 1, UDP-bound, gating loop inserted state==
 
<StructureSection load='8smp' size='340' side='right'caption='[[8smp]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
Authors: Gorniak, I., Zimmer, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8smp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SMP FirstGlance]. <br>
Description: Xenopus laevis hyaluronan synthase 1, UDP-bound, gating loop inserted state
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
[[Category: Zimmer, J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8smp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8smp OCA], [https://pdbe.org/8smp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8smp RCSB], [https://www.ebi.ac.uk/pdbsum/8smp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8smp ProSAT]</span></td></tr>
[[Category: Gorniak, I]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/HYAS1_XENLA HYAS1_XENLA] Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate.<ref>PMID:3410156</ref> <ref>PMID:9442026</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Xenopus laevis]]
[[Category: Gorniak I]]
[[Category: Zimmer J]]

Revision as of 09:22, 1 May 2024

Xenopus laevis hyaluronan synthase 1, UDP-bound, gating loop inserted stateXenopus laevis hyaluronan synthase 1, UDP-bound, gating loop inserted state

Structural highlights

8smp is a 3 chain structure with sequence from Homo sapiens and Xenopus laevis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.4Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HYAS1_XENLA Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate.[1] [2]

References

  1. ↑ Rosa F, Sargent TD, Rebbert ML, Michaels GS, Jamrich M, Grunz H, Jonas E, Winkles JA, Dawid IB. Accumulation and decay of DG42 gene products follow a gradient pattern during Xenopus embryogenesis. Dev Biol. 1988 Sep;129(1):114-23. PMID:3410156 doi:10.1016/0012-1606(88)90166-2
  2. ↑ Spicer AP, McDonald JA. Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family. J Biol Chem. 1998 Jan 23;273(4):1923-32. PMID:9442026 doi:10.1074/jbc.273.4.1923

8smp, resolution 3.40Å

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OCA
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