Cullin-associated NEDD8-disassociated protein: Difference between revisions
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== Function == | == Function == | ||
'''Cullin-associated NEDD8-disassociated protein 1''' (CAND1) is a protein exchange factor that accelerates the rate at which cullin1-Rbx1 equilibrates with multiple F-box proteins and thus controls the SCF ubiquitin ligase repertoire<ref>PMID:23453757</ref>. CAND1 plays a vital role in cullin-RING E3 ligase ubiquitin proteasome systems which control protein degradation. | '''Cullin-associated NEDD8-disassociated protein 1''' (CAND1) is a protein exchange factor that accelerates the rate at which cullin1-Rbx1 equilibrates with multiple F-box proteins and thus controls the SCF ubiquitin ligase repertoire<ref>PMID:23453757</ref>. CAND1 plays a vital role in cullin-RING E3 ligase ubiquitin proteasome systems which control protein degradation. | ||
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
In plants, silencing CAND1 expression results in dwarfing, early flowering, low seed germination percentage and delayed germination<ref>PMID:31916084</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
Revision as of 10:02, 28 April 2024
FunctionCullin-associated NEDD8-disassociated protein 1 (CAND1) is a protein exchange factor that accelerates the rate at which cullin1-Rbx1 equilibrates with multiple F-box proteins and thus controls the SCF ubiquitin ligase repertoire[1]. CAND1 plays a vital role in cullin-RING E3 ligase ubiquitin proteasome systems which control protein degradation. DiseaseRelevanceIn plants, silencing CAND1 expression results in dwarfing, early flowering, low seed germination percentage and delayed germination[2]. Structural highlightsThis is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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ReferencesReferences
- ↑ Pierce NW, Lee JE, Liu X, Sweredoski MJ, Graham RL, Larimore EA, Rome M, Zheng N, Clurman BE, Hess S, Shan SO, Deshaies RJ. Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. Cell. 2013 Mar 28;153(1):206-15. PMID:23453757 doi:10.1016/j.cell.2013.02.024
- ↑ Cheng W, Yin S, Tu Y, Mei H, Wang Y, Yang Y. SlCAND1, encoding cullin-associated Nedd8-dissociated protein 1, regulates plant height, flowering time, seed germination, and root architecture in tomato. Plant Mol Biol. 2020 Mar;102(4-5):537-551. PMID:31916084 doi:10.1007/s11103-020-00963-7