Sandbox Ben Whiteside: Difference between revisions
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==Introduction== | ==Introduction== | ||
When consuming food, the human body is tasked with secreting hormones and chemical messengers that will help regulate homeostasis. After a meal, our body has to maintain homeostasis by reducing our blood glucose and signaling that we have consumed enough nutrients. During feeding, cells in the body will secrete the ligand, amylin. Amylin is a 37 amino acid glucoregulatory hormone that is produced within beta cells of the pancreas. When there is an influx of nutrients in the gastrointestinal tract, the ligand will bind to the heterodimeric receptor, activating the receptor and triggering the corresponding signaling cascade. The overall effect of this cascade is increased satiety, delayed gastric emptying, and inhibition of glucagon secretion. The amylin receptors are widely distributed throughout the central nervous system. The amylin g-protein coupled receptor <scene name='10/1038828/Entire_protein_scene/4'>(AMYR) </scene>is a heterodimeric protein containing a calcitonin receptor domain, as well as one of three receptor activity modifying proteins(RAMP 1,2, or 3). | When consuming food, the human body is tasked with secreting hormones and chemical messengers that will help regulate homeostasis. After a meal, our body has to maintain homeostasis by reducing our blood glucose and signaling that we have consumed enough nutrients. During feeding, cells in the body will secrete the ligand, amylin. [https://en.wikipedia.org/wiki/Amylin Amylin] is a 37 amino acid glucoregulatory hormone that is produced within beta cells of the pancreas. When there is an influx of nutrients in the gastrointestinal tract, the ligand will bind to the heterodimeric receptor, activating the receptor and triggering the corresponding signaling cascade. The overall effect of this cascade is increased satiety, delayed gastric emptying, and inhibition of glucagon secretion. The amylin receptors are widely distributed throughout the central nervous system. The amylin g-protein coupled receptor <scene name='10/1038828/Entire_protein_scene/4'>(AMYR) </scene>is a heterodimeric protein containing a calcitonin receptor domain, as well as one of three receptor activity modifying proteins (RAMP 1,2, or 3). | ||
<ref name=”Ransey”>PMID:28504306</ref> | <ref name=”Ransey”>PMID:28504306</ref> | ||
<ref name=”Cao”>PMID:35324283</ref> | <ref name=”Cao”>PMID:35324283</ref> | ||
[https://en.wikipedia.org/wiki/Amylin Amylin | [https://en.wikipedia.org/wiki/Amylin Amylin] | ||