1r2m: Difference between revisions

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<StructureSection load='1r2m' size='340' side='right'caption='[[1r2m]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
<StructureSection load='1r2m' size='340' side='right'caption='[[1r2m]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1r2m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hypocrea_jecorina Hypocrea jecorina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R2M FirstGlance]. <br>
<table><tr><td colspan='2'>[[1r2m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichoderma_reesei Trichoderma reesei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R2M FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r2m OCA], [https://pdbe.org/1r2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r2m RCSB], [https://www.ebi.ac.uk/pdbsum/1r2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r2m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r2m OCA], [https://pdbe.org/1r2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r2m RCSB], [https://www.ebi.ac.uk/pdbsum/1r2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r2m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/HYP2_HYPJE HYP2_HYPJE]] Responsible for spore hydrophobicity and protection.  
[https://www.uniprot.org/uniprot/HYP2_HYPJE HYP2_HYPJE] Responsible for spore hydrophobicity and protection.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r2m ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r2m ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Hydrophobins are proteins specific to filamentous fungi. Hydrophobins have several important roles in fungal physiology, for example, adhesion, formation of protective surface coatings, and the reduction of the surface tension of water, which allows growth of aerial structures. Hydrophobins show remarkable biophysical properties, for example, they are the most powerful surface-active proteins known. To this point the molecular basis of the function of this group of proteins has been largely unknown. We have now determined the crystal structure of the hydrophobin HFBII from Trichoderma reesei at 1.0 A resolution. HFBII has a novel, compact single domain structure containing one alpha-helix and four antiparallel beta-strands that completely envelop two disulfide bridges. The protein surface is mainly hydrophilic, but two beta-hairpin loops contain several conserved aliphatic side chains that form a flat hydrophobic patch that makes the molecule amphiphilic. The amphiphilicity of the HFBII molecule is expected to be a source for surface activity, and we suggest that the behavior of this surfactant is greatly enhanced by the self-assembly that is favored by the combination of size and rigidity. This mechanism of function is supported by atomic force micrographs that show highly ordered arrays of HFBII at the air water interface. The data presented show that much of the current views on structure function relations in hydrophobins must be re-evaluated.
Atomic resolution structure of the HFBII hydrophobin, a self-assembling amphiphile.,Hakanpaa J, Paananen A, Askolin S, Nakari-Setala T, Parkkinen T, Penttila M, Linder MB, Rouvinen J J Biol Chem. 2004 Jan 2;279(1):534-9. Epub 2003 Oct 10. PMID:14555650<ref>PMID:14555650</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1r2m" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hypocrea jecorina]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Askolin, S]]
[[Category: Trichoderma reesei]]
[[Category: Hakanpaa, J]]
[[Category: Askolin S]]
[[Category: Linder, M B]]
[[Category: Hakanpaa J]]
[[Category: Nakari-Setala, T]]
[[Category: Linder MB]]
[[Category: Paananen, A]]
[[Category: Nakari-Setala T]]
[[Category: Parkkinen, T]]
[[Category: Paananen A]]
[[Category: Penttila, M]]
[[Category: Parkkinen T]]
[[Category: Rouvinen, J]]
[[Category: Penttila M]]
[[Category: Amphiphile]]
[[Category: Rouvinen J]]
[[Category: Fungi]]
[[Category: Protein surfactant]]
[[Category: Self-assembly]]
[[Category: Surface active protein]]

Revision as of 09:08, 17 April 2024

Atomic resolution structure of the HFBII hydrophobin: a self-assembling amphiphileAtomic resolution structure of the HFBII hydrophobin: a self-assembling amphiphile

Structural highlights

1r2m is a 2 chain structure with sequence from Trichoderma reesei. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HYP2_HYPJE Responsible for spore hydrophobicity and protection.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1r2m, resolution 1.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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