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==STRUCTURE OF RicC3, NMR, 20 STRUCTURES==
==STRUCTURE OF RicC3, NMR, 20 STRUCTURES==
<StructureSection load='1psy' size='340' side='right'caption='[[1psy]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1psy' size='340' side='right'caption='[[1psy]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1psy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PSY FirstGlance]. <br>
<table><tr><td colspan='2'>[[1psy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PSY FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1psy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psy OCA], [https://pdbe.org/1psy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1psy RCSB], [https://www.ebi.ac.uk/pdbsum/1psy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1psy ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1psy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psy OCA], [https://pdbe.org/1psy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1psy RCSB], [https://www.ebi.ac.uk/pdbsum/1psy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1psy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/2SS_RICCO 2SS_RICCO]] 2S seed storage proteins.  
[https://www.uniprot.org/uniprot/2SS_RICCO 2SS_RICCO] 2S seed storage proteins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1psy ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1psy ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The three-dimensional structure in aqueous solution of recombinant (15)N labeled RicC3, a 2S albumin protein from the seeds of castor bean (Ricinus communis), has been determined by NMR methods. The computed structures were based on 1564 upper limit distance constraints derived from NOE cross-correlation intensities measured in the 2D-NOESY and 3D-HSQC-NOESY experiments, 70 phi torsion angle constraints obtained from (3)J(HNH)(alpha) couplings measured in the HNHA experiment, and 30 psi torsion angle constraints derived from (3)J(H)(alpha)(Ni+1) couplings measured in the HNHB experiment. The computed structures showed a RMSD radius of 0.64 A for the structural core. The resulting structure consists of five amphipatic helices arranged in a right-handed super helix, a folding motif first observed in nonspecific lipid transfer proteins. Different than the latter, RicC3 does have not an internal cavity, a fact that can be related to the exchange in the pairing of disulfide bridges in the segment.CXC. Previous attempts to determine high resolution structures of a 2S albumin protein by either X-ray crystallography or NMR methods failed because of the heterogeneity of the protein prepared from natural sources. Both 2S albumins and nonspecific lipid transfer proteins belong to the prolamine superfamily, some of whose members are food allergens. The solution structure for recombinant RicC3 determined here is a suitable representative structure for the broad family of seed 2S albumin proteins, which may help to establish meaningful relationships between structure and allergenicity. RicC3 is also the peptidic component of the immunomodulator Inmunoferon, a widely used pharmaceutical product, and its structure is expected to help understand its pharmaceutical activity.
Solution structure of RicC3, a 2S albumin storage protein from Ricinus communis.,Pantoja-Uceda D, Bruix M, Gimenez-Gallego G, Rico M, Santoro J Biochemistry. 2003 Dec 2;42(47):13839-47. PMID:14636051<ref>PMID:14636051</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1psy" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Albumin 3D structures|Albumin 3D structures]]
*[[Albumin 3D structures|Albumin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ricinus communis]]
[[Category: Ricinus communis]]
[[Category: Bruix, M]]
[[Category: Bruix M]]
[[Category: Gimenez-Gallego, G]]
[[Category: Gimenez-Gallego G]]
[[Category: Pantoja-Uceda, D]]
[[Category: Pantoja-Uceda D]]
[[Category: Rico, M]]
[[Category: Rico M]]
[[Category: Santoro, J]]
[[Category: Santoro J]]
[[Category: Albumin seed protein]]
[[Category: Plant protein]]
[[Category: Ricc3]]
[[Category: Seed storage protein]]

Latest revision as of 08:58, 17 April 2024

STRUCTURE OF RicC3, NMR, 20 STRUCTURESSTRUCTURE OF RicC3, NMR, 20 STRUCTURES

Structural highlights

1psy is a 1 chain structure with sequence from Ricinus communis. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

2SS_RICCO 2S seed storage proteins.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

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OCA
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