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==Solution Structure of UBL5 a human Ubiquitin-Like Protein==
==Solution Structure of UBL5 a human Ubiquitin-Like Protein==
<StructureSection load='1p0r' size='340' side='right'caption='[[1p0r]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='1p0r' size='340' side='right'caption='[[1p0r]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1p0r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P0R FirstGlance]. <br>
<table><tr><td colspan='2'>[[1p0r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P0R FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p0r OCA], [https://pdbe.org/1p0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p0r RCSB], [https://www.ebi.ac.uk/pdbsum/1p0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p0r ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p0r OCA], [https://pdbe.org/1p0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p0r RCSB], [https://www.ebi.ac.uk/pdbsum/1p0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p0r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UBL5_HUMAN UBL5_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p0r ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p0r ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
UBL5 is a widely expressed human protein that is strongly conserved across phylogeny. Orthologs of UBL5 occur in every eukaryotic genome characterized to date. The yeast ortholog of UBL5, HUB1, was reported to be a ubiquitin-like protein modifier important for modulation of protein function. However, unlike ubiquitin and all other ubiquitin-like modifiers, UBL5 and its yeast ortholog HUB1 both contain a C-terminal di-tyrosine motif followed by a single variable residue instead of the characteristic di-glycine found in all other ubiquitin-like modifiers. Here we describe the three-dimensional structure of UBL5 determined by NMR. The overall structure of the protein was found to be very similar to ubiquitin despite the low approximately 25% residue similarity. The signature C-terminal di-tyrosine residues in UBL5 are involved in the final beta sheet of the protein. This is very different to the di-glycine motif found in ubiquitin, which extends beyond the final beta sheet. In addition, we have confirmed an earlier report of an interaction between UBL5 and the cyclin-like kinase, CLK4, which we have determined is specific and does not extend to other cyclin-like kinase family members.
Structural analysis of UBL5, a novel ubiquitin-like modifier.,McNally T, Huang Q, Janis RS, Liu Z, Olejniczak ET, Reilly RM Protein Sci. 2003 Jul;12(7):1562-6. PMID:12824502<ref>PMID:12824502</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1p0r" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Huang, Q]]
[[Category: Huang Q]]
[[Category: Janis, R S]]
[[Category: Janis RS]]
[[Category: Liu, Z]]
[[Category: Liu Z]]
[[Category: McNally, T]]
[[Category: McNally T]]
[[Category: Olejniczak, E T]]
[[Category: Olejniczak ET]]
[[Category: Reilly, R M]]
[[Category: Reilly RM]]
[[Category: Protein binding]]
[[Category: Ubiquitin-like fold]]

Revision as of 08:52, 17 April 2024

Solution Structure of UBL5 a human Ubiquitin-Like ProteinSolution Structure of UBL5 a human Ubiquitin-Like Protein

Structural highlights

1p0r is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

UBL5_HUMAN

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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OCA
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