1ouu: Difference between revisions

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<StructureSection load='1ouu' size='340' side='right'caption='[[1ouu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1ouu' size='340' side='right'caption='[[1ouu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ouu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Oncmy Oncmy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OUU FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ouu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Oncorhynchus_mykiss Oncorhynchus mykiss]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OUU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ouu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ouu OCA], [https://pdbe.org/1ouu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ouu RCSB], [https://www.ebi.ac.uk/pdbsum/1ouu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ouu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ouu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ouu OCA], [https://pdbe.org/1ouu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ouu RCSB], [https://www.ebi.ac.uk/pdbsum/1ouu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ouu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/HBA1_ONCMY HBA1_ONCMY]] Involved in oxygen transport from gills to the various peripheral tissues. [[https://www.uniprot.org/uniprot/HBB1_ONCMY HBB1_ONCMY]] Involved in oxygen transport from gills to the various peripheral tissues.  
[https://www.uniprot.org/uniprot/HBA1_ONCMY HBA1_ONCMY] Involved in oxygen transport from gills to the various peripheral tissues.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ouu ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ouu ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We have determined the X-ray crystallographic structure of trout Hb I in both the deoxy and carbonmonoxy forms to resolution limits of 2.3 angstroms and 2.5 angstroms, respectively. The overall fold of the molecule is highly similar to that of human HbA despite the low level of sequence identity between these proteins. Trout Hb I is unusual in displaying almost no pH dependence of oxygen binding affinity, and (at most) very weak interactions with heterotropic effector ligands such as organic phosphates. Comparison of the two quaternary states of the protein indicates how such effects are minimised and how the low-affinity T state of the protein is stabilised in the absence of heterotropic interactions.
The crystal structures of trout Hb I in the deoxy and carbonmonoxy forms.,Tame JR, Wilson JC, Weber RE J Mol Biol. 1996 Jun 21;259(4):749-60. PMID:8683580<ref>PMID:8683580</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1ouu" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Oncmy]]
[[Category: Oncorhynchus mykiss]]
[[Category: Tame, J]]
[[Category: Tame J]]
[[Category: Wilson, J]]
[[Category: Wilson J]]
[[Category: Erythrocyte]]
[[Category: Heme]]
[[Category: Oxygen transport]]
[[Category: Respiratory protein]]

Revision as of 08:50, 17 April 2024

CARBONMONOXY TROUT HEMOGLOBIN ICARBONMONOXY TROUT HEMOGLOBIN I

Structural highlights

1ouu is a 4 chain structure with sequence from Oncorhynchus mykiss. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HBA1_ONCMY Involved in oxygen transport from gills to the various peripheral tissues.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1ouu, resolution 2.50Å

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