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The entry | ==Structure of human calcium-sensing receptor in complex with Gi1 (miniGi1) protein in detergent== | ||
<StructureSection load='9ayf' size='340' side='right'caption='[[9ayf]], [[Resolution|resolution]] 3.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ayf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9AYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9AYF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9IG:3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine'>9IG</scene>, <scene name='pdbligand=AV0:Lauryl+Maltose+Neopentyl+Glycol'>AV0</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TCR:CYCLOMETHYLTRYPTOPHAN'>TCR</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ayf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ayf OCA], [https://pdbe.org/9ayf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ayf RCSB], [https://www.ebi.ac.uk/pdbsum/9ayf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ayf ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/CASR_HUMAN CASR_HUMAN] Autosomal dominant hypocalcemia;Familial isolated hypoparathyroidism due to impaired PTH secretion;Neonatal severe primary hyperparathyroidism;Familial hypocalciuric hypercalcemia type 1;Bartter syndrome with hypocalcemia. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Homozygous defects in CASR can be a cause of primary hyperparathyroidism in adulthood. Patients suffer from osteoporosis and renal calculi, have marked hypercalcemia and increased serum PTH concentrations. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CASR_HUMAN CASR_HUMAN] Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Asher WB]] | |||
[[Category: Clarke OB]] | |||
[[Category: Conigrave AD]] | |||
[[Category: Eng E]] | |||
[[Category: Fan QR]] | |||
[[Category: Frangaj A]] | |||
[[Category: Grasucci R]] | |||
[[Category: Hendrickson WA]] | |||
[[Category: Hu G]] | |||
[[Category: Javitch JA]] | |||
[[Category: Lin X]] | |||
[[Category: Lu G]] | |||
[[Category: Lu Z]] | |||
[[Category: Manning JJ]] | |||
[[Category: Mendez J]] | |||
[[Category: Park J]] | |||
[[Category: Wang L]] | |||
[[Category: Ye J]] | |||
[[Category: Zhang Z]] | |||
[[Category: Zuo H]] | |||
Revision as of 08:32, 17 April 2024
Structure of human calcium-sensing receptor in complex with Gi1 (miniGi1) protein in detergentStructure of human calcium-sensing receptor in complex with Gi1 (miniGi1) protein in detergent
Structural highlights
DiseaseCASR_HUMAN Autosomal dominant hypocalcemia;Familial isolated hypoparathyroidism due to impaired PTH secretion;Neonatal severe primary hyperparathyroidism;Familial hypocalciuric hypercalcemia type 1;Bartter syndrome with hypocalcemia. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Homozygous defects in CASR can be a cause of primary hyperparathyroidism in adulthood. Patients suffer from osteoporosis and renal calculi, have marked hypercalcemia and increased serum PTH concentrations. FunctionCASR_HUMAN Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. |
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