1rmd: Difference between revisions

Revision as of 07:39, 3 May 2008

RAG1 DIMERIZATION DOMAIN

OverviewOverview

The crystal structure of the dimerization domain of the V(D)J recombination-activating protein, RAG1, was solved using zinc anomalous scattering. The structure reveals an unusual combination of multi-class zinc-binding motifs, including a zinc RING finger and a C2H2 zinc finger, that together from a single structural domain. The domain also contains a unique zinc binuclear cluster in place of a normally mononuclear zinc site in the RING finger. Together, four zinc ions help organize the entire domain, including the two helices that form the dimer interface.

About this StructureAbout this Structure

1RMD is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster., Bellon SF, Rodgers KK, Schatz DG, Coleman JE, Steitz TA, Nat Struct Biol. 1997 Jul;4(7):586-91. PMID:9228952 Page seeded by OCA on Sat May 3 07:39:56 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1rmd.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1rmd |SIZE=350|CAPTION= <scene name='initialview01'>1rmd</scene>, resolution 2.10&Aring;
+The line below this paragraph, containing "STRUCTURE_1rmd", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1rmd|  PDB=1rmd  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rmd OCA], [http://www.ebi.ac.uk/pdbsum/1rmd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rmd RCSB]</span>
-}}
 '''RAG1 DIMERIZATION DOMAIN'''
@@ Line 30: / Line 27: @@
 [[Category: Schatz, D G.]]
 [[Category: Steitz, T A.]]
-[[Category: antibody]]
+[[Category: Antibody]]
-[[Category: dna-binding protein]]
+[[Category: Dna-binding protein]]
-[[Category: mad]]
+[[Category: Mad]]
-[[Category: rag1]]
+[[Category: Rag1]]
-[[Category: ring finger]]
+[[Category: Ring finger]]
-[[Category: v(d)j recombination]]
+[[Category: Zinc binuclear cluster]]
-[[Category: zinc binuclear cluster]]
+[[Category: Zinc finger]]
-[[Category: zinc finger]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:39:56 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:30:08 2008''