Proteopedia

1moz: Difference between revisions

← Older editNewer edit →
No edit summary
No edit summary
Line 3: Line 3:
<StructureSection load='1moz' size='340' side='right'caption='[[1moz]], [[Resolution|resolution]] 3.17&Aring;' scene=''>
<StructureSection load='1moz' size='340' side='right'caption='[[1moz]], [[Resolution|resolution]] 3.17&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1moz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MOZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[1moz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MOZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.17&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rrf|1rrf]], [[1hur|1hur]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1moz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1moz OCA], [https://pdbe.org/1moz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1moz RCSB], [https://www.ebi.ac.uk/pdbsum/1moz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1moz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1moz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1moz OCA], [https://pdbe.org/1moz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1moz RCSB], [https://www.ebi.ac.uk/pdbsum/1moz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1moz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ARL1_YEAST ARL1_YEAST]] Recruits golgins such as IMH1 to the Golgi. Can bind and hydrolyze GTP. May be involved in trafficking events within the endosomal system.<ref>PMID:12052896</ref> <ref>PMID:12620188</ref> <ref>PMID:12620189</ref>
[https://www.uniprot.org/uniprot/ARL1_YEAST ARL1_YEAST] Recruits golgins such as IMH1 to the Golgi. Can bind and hydrolyze GTP. May be involved in trafficking events within the endosomal system.<ref>PMID:12052896</ref> <ref>PMID:12620188</ref> <ref>PMID:12620189</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 20: Line 20:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1moz ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1moz ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Structures were determined by x-ray crystallography for two members of the ADP-ribosylation factor (ARF) family of regulatory GTPases, yeast ARF1 and ARL1, and were compared with previously determined structures of human ARF1 and ARF6. These analyses revealed an overall conserved fold but differences in primary sequence and length, particularly in an N-terminal loop, lead to differences in nucleotide and divalent metal binding. Packing of hydrophobic residues is central to the interplay between the N-terminal alpha-helix, switch I, and the interswitch region, which along with differences in surface electrostatics provide explanations for the different biophysical and biochemical properties of ARF and ARF-like proteins.
Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases.,Amor JC, Horton JR, Zhu X, Wang Y, Sullards C, Ringe D, Cheng X, Kahn RA J Biol Chem. 2001 Nov 9;276(45):42477-84. Epub 2001 Sep 4. PMID:11535602<ref>PMID:11535602</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1moz" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Amor, J C]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Cheng, X]]
[[Category: Amor JC]]
[[Category: Horton, J R]]
[[Category: Cheng X]]
[[Category: Kahn, R A]]
[[Category: Horton JR]]
[[Category: Ringe, D]]
[[Category: Kahn RA]]
[[Category: Sullards, C]]
[[Category: Ringe D]]
[[Category: Wang, Y]]
[[Category: Sullards C]]
[[Category: Zhu, X]]
[[Category: Wang Y]]
[[Category: Gtp-binding]]
[[Category: Zhu X]]
[[Category: Protein binding]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/w/1moz"