1m3b: Difference between revisions

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OCA

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 ==Solution structure of a circular form of the N-terminal SH3 domain (A134C, E135G, R191G mutant) from oncogene protein c-Crk.==
-<StructureSection load='1m3b' size='340' side='right'caption='[[1m3b]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='1m3b' size='340' side='right'caption='[[1m3b]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1m3b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M3B FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1m3b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M3B FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m30|1m30]], [[1m3a|1m3a]], [[1m3c|1m3c]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CRK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m3b OCA], [https://pdbe.org/1m3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m3b RCSB], [https://www.ebi.ac.uk/pdbsum/1m3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m3b ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/CRK_MOUSE CRK_MOUSE]] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
+[https://www.uniprot.org/uniprot/CRK_MOUSE CRK_MOUSE] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 26: / Line 25: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Lk3 transgenic mice]]
+[[Category: Mus musculus]]
-[[Category: Camarero, J A]]
+[[Category: Camarero JA]]
-[[Category: Fushman, D]]
+[[Category: Fushman D]]
-[[Category: Hall, J B]]
+[[Category: Hall JB]]
-[[Category: Schumann, F H]]
+[[Category: Schumann FH]]
-[[Category: Tayakuniyil, P P]]
+[[Category: Tayakuniyil PP]]
-[[Category: Varadan, R]]
+[[Category: Varadan R]]
-[[Category: Adaptor protein]]
-[[Category: Circular protein]]
-[[Category: Cyclized protein]]
-[[Category: Protein binding]]
-[[Category: Sh3]]
-[[Category: Sh3 domain]]