1la2: Difference between revisions

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<StructureSection load='1la2' size='340' side='right'caption='[[1la2]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
<StructureSection load='1la2' size='340' side='right'caption='[[1la2]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1la2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LA2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1LA2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1la2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LA2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">INO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1la2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1la2 OCA], [https://pdbe.org/1la2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1la2 RCSB], [https://www.ebi.ac.uk/pdbsum/1la2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1la2 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1la2 TOPSAN]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-3-phosphate_synthase Inositol-3-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.5.1.4 5.5.1.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1la2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1la2 OCA], [http://pdbe.org/1la2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1la2 RCSB], [http://www.ebi.ac.uk/pdbsum/1la2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1la2 ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/1la2 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/INO1_YEAST INO1_YEAST]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1la2 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1la2 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The New York Structural Genomics Research Consortium has targeted highly conserved but uncharacterized enzyme families for structure determination. As part of this effort, the 2.65-A crystal structure has been determined for Saccharomyces cerevisiae myo-inositol 1-phosphate synthase (MIP), an essential enzyme that catalyzes critical steps in inositol biosynthesis. The structure determination of four independent monomers in the asymmetric unit (240 kDa) reveals atomic details and residue composition for the partially closed NAD-containing active sites in apo-configuration. The structure further reveals extensive interactions involved in tetrameric assembly of the enzyme complex.
Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase.,Kniewel R, Buglino JA, Shen V, Chadha T, Beckwith A, Lima CD J Struct Funct Genomics. 2002;2(3):129-34. PMID:12836703<ref>PMID:12836703</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1la2" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Inositol-3-phosphate synthase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Beckwith, A]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Buglino, J A]]
[[Category: Beckwith A]]
[[Category: Burley, S K]]
[[Category: Buglino JA]]
[[Category: Chadna, T]]
[[Category: Burley SK]]
[[Category: Kniewel, R]]
[[Category: Chadna T]]
[[Category: Lima, C D]]
[[Category: Kniewel R]]
[[Category: Structural genomic]]
[[Category: Lima CD]]
[[Category: Shen, V]]
[[Category: Shen V]]
[[Category: Ino1]]
[[Category: Inositol]]
[[Category: Isomerase]]
[[Category: Metabolism]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
[[Category: PSI, Protein structure initiative]]
[[Category: Yeast]]

Revision as of 11:07, 3 April 2024

Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthaseStructural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase

Structural highlights

1la2 is a 4 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.65Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

INO1_YEAST

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1la2, resolution 2.65Å

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OCA
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