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==Solution NMR Structure of BRCT Domain of T. Thermophilus: Northeast Structural Genomics Consortium Target WR64TT==
==Solution NMR Structure of BRCT Domain of T. Thermophilus: Northeast Structural Genomics Consortium Target WR64TT==
<StructureSection load='1l7b' size='340' side='right'caption='[[1l7b]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='1l7b' size='340' side='right'caption='[[1l7b]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1l7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L7B FirstGlance]. <br>
<table><tr><td colspan='2'>[[1l7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L7B FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DNLJ ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 "Flavobacterium thermophilum" Yoshida and Oshima 1971])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA_ligase_(NAD(+)) DNA ligase (NAD(+))], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.2 6.5.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l7b OCA], [https://pdbe.org/1l7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l7b RCSB], [https://www.ebi.ac.uk/pdbsum/1l7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l7b ProSAT], [https://www.topsan.org/Proteins/NESGC/1l7b TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l7b OCA], [https://pdbe.org/1l7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l7b RCSB], [https://www.ebi.ac.uk/pdbsum/1l7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l7b ProSAT], [https://www.topsan.org/Proteins/NESGC/1l7b TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DNLJ_THET8 DNLJ_THET8]] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.  
[https://www.uniprot.org/uniprot/DNLJ_THET8 DNLJ_THET8] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Anderson, S]]
[[Category: Thermus thermophilus]]
[[Category: Aramini, J]]
[[Category: Anderson S]]
[[Category: Bhattacharya, D]]
[[Category: Aramini J]]
[[Category: Dixon, B L]]
[[Category: Bhattacharya D]]
[[Category: Huang, Y P]]
[[Category: Dixon BL]]
[[Category: Monleon, D]]
[[Category: Huang YP]]
[[Category: Montelione, G T]]
[[Category: Monleon D]]
[[Category: Structural genomic]]
[[Category: Montelione GT]]
[[Category: Sahota, G]]
[[Category: Sahota G]]
[[Category: Swapna, G V.T]]
[[Category: Swapna GVT]]
[[Category: Tejero, R]]
[[Category: Tejero R]]
[[Category: Xiao, R]]
[[Category: Xiao R]]
[[Category: Yin, C]]
[[Category: Yin C]]
[[Category: Autostructure]]
[[Category: Brct]]
[[Category: Dna ligase]]
[[Category: Ligase]]
[[Category: Nesg]]
[[Category: PSI, Protein structure initiative]]

Latest revision as of 11:07, 3 April 2024

Solution NMR Structure of BRCT Domain of T. Thermophilus: Northeast Structural Genomics Consortium Target WR64TTSolution NMR Structure of BRCT Domain of T. Thermophilus: Northeast Structural Genomics Consortium Target WR64TT

Structural highlights

1l7b is a 1 chain structure with sequence from Thermus thermophilus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

DNLJ_THET8 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

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