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==NMR STRUCTURE OF MOUSE DOPPEL 51-157==
==NMR STRUCTURE OF MOUSE DOPPEL 51-157==
<StructureSection load='1i17' size='340' side='right'caption='[[1i17]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1i17' size='340' side='right'caption='[[1i17]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1i17]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I17 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1i17]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I17 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i17 OCA], [https://pdbe.org/1i17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i17 RCSB], [https://www.ebi.ac.uk/pdbsum/1i17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i17 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i17 OCA], [https://pdbe.org/1i17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i17 RCSB], [https://www.ebi.ac.uk/pdbsum/1i17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i17 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRND_MOUSE PRND_MOUSE]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i17 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i17 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The downstream prion-like protein (doppel, or Dpl) is a paralog of the cellular prion protein, PrP(C). The two proteins have approximately 25% sequence identity, but seem to have distinct physiologic roles. Unlike PrP(C), Dpl does not support prion replication; instead, overexpression of Dpl in the brain seems to cause a completely different neurodegenerative disease. We report the solution structure of a fragment of recombinant mouse Dpl (residues 26-157) containing a globular domain with three helices and a small amount of beta-structure. Overall, the topology of Dpl is very similar to that of PrP(C). Significant differences include a marked kink in one of the helices in Dpl, and a different orientation of the two short beta-strands. Although the two proteins most likely arose through duplication of a single ancestral gene, the relationship is now so distant that only the structures retain similarity; the functions have diversified along with the sequence.
Two different neurodegenerative diseases caused by proteins with similar structures.,Mo H, Moore RC, Cohen FE, Westaway D, Prusiner SB, Wright PE, Dyson HJ Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2352-7. PMID:11226243<ref>PMID:11226243</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1i17" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Cohen, F E]]
[[Category: Cohen FE]]
[[Category: Dyson, H J]]
[[Category: Dyson HJ]]
[[Category: Mo, H]]
[[Category: Mo H]]
[[Category: Moore, R C]]
[[Category: Moore RC]]
[[Category: Prusiner, S B]]
[[Category: Prusiner SB]]
[[Category: Westaway, D]]
[[Category: Westaway D]]
[[Category: Wright, P E]]
[[Category: Wright PE]]
[[Category: Doppel]]
[[Category: Dpl]]
[[Category: Mouse doppel]]
[[Category: Prion]]
[[Category: Unknown function]]

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