1h21: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1h21]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfovibrio_desulfuricans Desulfovibrio desulfuricans]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ddc 1ddc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H21 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1h21]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfovibrio_desulfuricans Desulfovibrio desulfuricans]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ddc 1ddc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H21 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ddc|1ddc]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h21 OCA], [https://pdbe.org/1h21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h21 RCSB], [https://www.ebi.ac.uk/pdbsum/1h21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h21 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h21 OCA], [https://pdbe.org/1h21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h21 RCSB], [https://www.ebi.ac.uk/pdbsum/1h21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h21 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CYCX_DESDA CYCX_DESDA]] Diheme cytochrome c which may be involved in sulfate reduction.  
[https://www.uniprot.org/uniprot/CYCX_DESDA CYCX_DESDA] Diheme cytochrome c which may be involved in sulfate reduction.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h21 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h21 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The facultative sulfate/nitrate-reducing bacterium Desulfovibrio desulfuricans ATCC 27774 harbours a split-Soret cytochrome c. This cytochrome is a homodimeric protein, having two bis-histidinyl c-type haems per monomer. It has an unique architecture at the haem domain: each haem has one of the coordinating histidines provided by the other monomer, and in each monomer the haems are parallel to each other, almost in van der Waals contact. This work reports the cloning and sequencing of the gene encoding for this cytochrome and shows, by transcriptional analysis, that it is more expressed in nitrate-grown cells than in sulfate-grown ones. In addition, the gene-deduced amino acid sequence revealed two new cysteine residues that could be involved in the binding of a non-haem iron centre. Indeed, the presence of a novel type of an iron-sulfur centre (possibly of the [2Fe-2S] type) was demonstrated by EPR spectroscopy, and putative models for its localization and structure in the cytochrome molecule are proposed on the basis of the so-far-known 3D crystallographic structure of the aerobically purified split-Soret cytochrome, which lacks this centre.
A novel iron centre in the split-Soret cytochrome c from Desulfovibrio desulfuricans ATCC 27774.,Abreu IA, Lourenco AI, Xavier AV, LeGall J, Coelho AV, Matias PM, Pinto DM, Armenia Carrondo M, Teixeira M, Saraiva LM J Biol Inorg Chem. 2003 Feb;8(3):360-70. Epub 2002 Dec 19. PMID:12589573<ref>PMID:12589573</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1h21" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Desulfovibrio desulfuricans]]
[[Category: Desulfovibrio desulfuricans]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Abreu, I A]]
[[Category: Abreu IA]]
[[Category: Carrondo, M A]]
[[Category: Carrondo MA]]
[[Category: Coelho, A V]]
[[Category: Coelho AV]]
[[Category: Legall, J]]
[[Category: Legall J]]
[[Category: Lourenco, A I]]
[[Category: Lourenco AI]]
[[Category: Matias, P M]]
[[Category: Matias PM]]
[[Category: Pinto, D M]]
[[Category: Pinto DM]]
[[Category: Saraiva, L M]]
[[Category: Saraiva LM]]
[[Category: Teixeira, M]]
[[Category: Teixeira M]]
[[Category: Xavier, A V]]
[[Category: Xavier AV]]
[[Category: Cytochrome]]
[[Category: Dimeric di-heme cytochrome]]
[[Category: Electron transport]]
[[Category: Novel fold]]
[[Category: Novel iron-sulfur centre]]
[[Category: Stacked heme arrangement]]
[[Category: Sulfate respiration]]

Latest revision as of 14:27, 27 March 2024

A novel iron centre in the split-Soret cytochrome c from Desulfovibrio desulfuricans ATCC 27774A novel iron centre in the split-Soret cytochrome c from Desulfovibrio desulfuricans ATCC 27774

Structural highlights

1h21 is a 4 chain structure with sequence from Desulfovibrio desulfuricans. This structure supersedes the now removed PDB entry 1ddc. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CYCX_DESDA Diheme cytochrome c which may be involved in sulfate reduction.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1h21, resolution 2.50Å

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