7da4: Difference between revisions
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==Cryo-EM structure of amyloid fibril formed by human RIPK3== | ==Cryo-EM structure of amyloid fibril formed by human RIPK3== | ||
<StructureSection load='7da4' size='340' side='right'caption='[[7da4]]' scene=''> | <StructureSection load='7da4' size='340' side='right'caption='[[7da4]], [[Resolution|resolution]] 4.24Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DA4 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7da4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DA4 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7da4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7da4 OCA], [https://pdbe.org/7da4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7da4 RCSB], [https://www.ebi.ac.uk/pdbsum/7da4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7da4 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.24Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7da4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7da4 OCA], [https://pdbe.org/7da4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7da4 RCSB], [https://www.ebi.ac.uk/pdbsum/7da4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7da4 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/RIPK3_HUMAN RIPK3_HUMAN] Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.<ref>PMID:19498109</ref> <ref>PMID:19524512</ref> <ref>PMID:19524513</ref> <ref>PMID:22265413</ref> <ref>PMID:22265414</ref> <ref>PMID:22421439</ref> | |||
==See Also== | |||
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Li D]] | [[Category: Li D]] | ||