7d20: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==== | ==Cryo-EM structure of SET8-CENP-A-nucleosome complex== | ||
<StructureSection load='7d20' size='340' side='right'caption='[[7d20]]' scene=''> | <StructureSection load='7d20' size='340' side='right'caption='[[7d20]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7d20]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D20 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d20 OCA], [https://pdbe.org/7d20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d20 RCSB], [https://www.ebi.ac.uk/pdbsum/7d20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d20 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d20 OCA], [https://pdbe.org/7d20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d20 RCSB], [https://www.ebi.ac.uk/pdbsum/7d20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d20 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CENPA_HUMAN CENPA_HUMAN] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).<ref>PMID:20739937</ref> <ref>PMID:21478274</ref> | |||
==See Also== | |||
*[[Centromere protein 3D structure|Centromere protein 3D structure]] | |||
*[[Histone 3D structures|Histone 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: Arimura Y]] | |||
[[Category: Ho C-H]] | |||
[[Category: Kobayashi W]] | |||
[[Category: Kurumizaka H]] | |||
[[Category: Takizawa Y]] | |||