7cb0: Difference between revisions

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<StructureSection load='7cb0' size='340' side='right'caption='[[7cb0]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
<StructureSection load='7cb0' size='340' side='right'caption='[[7cb0]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7cb0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staae Staae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CB0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CB0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[7cb0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_str._Newman Staphylococcus aureus subsp. aureus str. Newman]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CB0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CB0 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gnd, NWMN_1417 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=426430 STAAE])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.52&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cb0 OCA], [https://pdbe.org/7cb0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cb0 RCSB], [https://www.ebi.ac.uk/pdbsum/7cb0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cb0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cb0 OCA], [https://pdbe.org/7cb0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cb0 RCSB], [https://www.ebi.ac.uk/pdbsum/7cb0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cb0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/A0A0H3KGN1_STAAE A0A0H3KGN1_STAAE]] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.[PIRNR:PIRNR000109]  
[https://www.uniprot.org/uniprot/A0A0H3KGN1_STAAE A0A0H3KGN1_STAAE] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.[PIRNR:PIRNR000109]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The rapid emergence of drug resistant Staphylococcus aureus (S. aureus) poses a serious threat to public health globally. Silver (Ag)-based antimicrobials are promising to combat antibiotic resistant S. aureus, yet their molecular targets are largely elusive. Herein, we separate and identify 38 authentic Ag(+)-binding proteins in S. aureus at the whole-cell scale. We then capture the molecular snapshot on the dynamic action of Ag(+) against S. aureus and further validate that Ag(+) could inhibit a key target 6-phosphogluconate dehydrogenase through binding to catalytic His185 by X-ray crystallography. Significantly, the multi-target mode of action of Ag(+) (and nanosilver) endows its sustainable antimicrobial efficacy, leading to enhanced efficacy of conventional antibiotics and resensitization of MRSA to antibiotics. Our study resolves the long-standing question of the molecular targets of silver in S. aureus and offers insights into the sustainable bacterial susceptibility of silver, providing a potential approach for combating antimicrobial resistance.


Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance.,Wang H, Wang M, Xu X, Gao P, Xu Z, Zhang Q, Li H, Yan A, Kao RY, Sun H Nat Commun. 2021 Jun 7;12(1):3331. doi: 10.1038/s41467-021-23659-y. PMID:34099682<ref>PMID:34099682</ref>
==See Also==
 
*[[6-phosphogluconate dehydrogenase 3D structures|6-phosphogluconate dehydrogenase 3D structures]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7cb0" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Staae]]
[[Category: Staphylococcus aureus subsp. aureus str. Newman]]
[[Category: Sun, H]]
[[Category: Sun H]]
[[Category: Wang, H]]
[[Category: Wang H]]
[[Category: Wang, M]]
[[Category: Wang M]]
[[Category: Cytosolic protein]]
[[Category: Decarboxylating]]
[[Category: Pentose phosphate pathway]]

Latest revision as of 13:50, 27 March 2024

The apo 6-phosphogluconate dehydrogenase from Staphylococcus aureus (strain Newman)The apo 6-phosphogluconate dehydrogenase from Staphylococcus aureus (strain Newman)

Structural highlights

7cb0 is a 4 chain structure with sequence from Staphylococcus aureus subsp. aureus str. Newman. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.52Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A0A0H3KGN1_STAAE Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.[PIRNR:PIRNR000109]

See Also

7cb0, resolution 2.52Å

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OCA
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