8too: Difference between revisions

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'''Unreleased structure'''


The entry 8too is ON HOLD  until Paper Publication
==Crystal structure of Epstein-Barr virus gp42 in complex with antibody 4C12==
 
<StructureSection load='8too' size='340' side='right'caption='[[8too]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8too]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TOO FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8too FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8too OCA], [https://pdbe.org/8too PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8too RCSB], [https://www.ebi.ac.uk/pdbsum/8too PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8too ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GP42_EBVB9 GP42_EBVB9] Plays a role in virion attachment to host B-lymphocytes, through binding to leukocyte antigen (HLA) class II and subsequently participates in fusion of the virion with host membranes. May act as a tropism switch that directs fusion with B-lymphocytes and inhibits fusion with epithelial cells.<ref>PMID:12042810</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human gammaherpesvirus 4]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Board N]]
[[Category: Bu W]]
[[Category: Cohen JI]]
[[Category: Dowdell K]]
[[Category: Hostal A]]
[[Category: Kim J]]
[[Category: Krogmann T]]
[[Category: Kumar A]]
[[Category: Lei Y]]
[[Category: Marcotrigiano J]]
[[Category: Pittaluga S]]
[[Category: Wang Y]]
[[Category: Zhang S]]

Latest revision as of 13:13, 27 March 2024

Crystal structure of Epstein-Barr virus gp42 in complex with antibody 4C12Crystal structure of Epstein-Barr virus gp42 in complex with antibody 4C12

Structural highlights

8too is a 12 chain structure with sequence from Human gammaherpesvirus 4 and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GP42_EBVB9 Plays a role in virion attachment to host B-lymphocytes, through binding to leukocyte antigen (HLA) class II and subsequently participates in fusion of the virion with host membranes. May act as a tropism switch that directs fusion with B-lymphocytes and inhibits fusion with epithelial cells.[1]

References

  1. ↑ Borza CM, Hutt-Fletcher LM. Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus. Nat Med. 2002 Jun;8(6):594-9. PMID:12042810 doi:10.1038/nm0602-594

8too, resolution 2.60Å

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OCA
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