8w3v: Difference between revisions

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'''Unreleased structure'''


The entry 8w3v is ON HOLD
==Crystal structure of human WDR41==
 
<StructureSection load='8w3v' size='340' side='right'caption='[[8w3v]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
Authors: Hutchinson, A., Dong, A., Li, Y., Seitova, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Halabelian, L., Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8w3v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6whh 6whh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W3V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W3V FirstGlance]. <br>
Description: Crystal structure of human WDR41
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w3v OCA], [https://pdbe.org/8w3v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w3v RCSB], [https://www.ebi.ac.uk/pdbsum/8w3v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w3v ProSAT]</span></td></tr>
[[Category: Hutchinson, A]]
</table>
[[Category: Edwards, A.M]]
== Function ==
[[Category: Arrowsmith, C.H]]
[https://www.uniprot.org/uniprot/WDR41_HUMAN WDR41_HUMAN] Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292).<ref>PMID:27103069</ref> <ref>PMID:27193190</ref> <ref>PMID:27617292</ref> <ref>PMID:28195531</ref>
[[Category: Seitova, A]]
== References ==
[[Category: Dong, A]]
<references/>
[[Category: Structural Genomics Consortium (Sgc)]]
__TOC__
[[Category: Li, Y]]
</StructureSection>
[[Category: Halabelian, L]]
[[Category: Homo sapiens]]
[[Category: Bountra, C]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Dong A]]
[[Category: Edwards AM]]
[[Category: Halabelian L]]
[[Category: Hutchinson A]]
[[Category: Li Y]]
[[Category: Seitova A]]

Latest revision as of 13:06, 27 March 2024

Crystal structure of human WDR41Crystal structure of human WDR41

Structural highlights

8w3v is a 2 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 6whh. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

WDR41_HUMAN Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292).[1] [2] [3] [4]

References

  1. ↑ Sellier C, Campanari ML, Julie Corbier C, Gaucherot A, Kolb-Cheynel I, Oulad-Abdelghani M, Ruffenach F, Page A, Ciura S, Kabashi E, Charlet-Berguerand N. Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death. EMBO J. 2016 Jun 15;35(12):1276-97. doi: 10.15252/embj.201593350. Epub 2016 Apr, 21. PMID:27103069 doi:http://dx.doi.org/10.15252/embj.201593350
  2. ↑ Sullivan PM, Zhou X, Robins AM, Paushter DH, Kim D, Smolka MB, Hu F. The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway. Acta Neuropathol Commun. 2016 May 18;4(1):51. doi: 10.1186/s40478-016-0324-5. PMID:27193190 doi:http://dx.doi.org/10.1186/s40478-016-0324-5
  3. ↑ Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F, Shiekhattar R, Chen JF. A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. Sci Adv. 2016 Sep 2;2(9):e1601167. doi: 10.1126/sciadv.1601167. eCollection 2016 , Sep. PMID:27617292 doi:http://dx.doi.org/10.1126/sciadv.1601167
  4. ↑ Jung J, Nayak A, Schaeffer V, Starzetz T, Kirsch AK, Muller S, Dikic I, Mittelbronn M, Behrends C. Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Elife. 2017 Feb 14;6. doi: 10.7554/eLife.23063. PMID:28195531 doi:http://dx.doi.org/10.7554/eLife.23063

8w3v, resolution 2.20Å

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