1fc6: Difference between revisions

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<StructureSection load='1fc6' size='340' side='right'caption='[[1fc6]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='1fc6' size='340' side='right'caption='[[1fc6]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1fc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Achnanthes_obliqua Achnanthes obliqua]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FC6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1fc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetradesmus_obliquus Tetradesmus obliquus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FC6 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fc7|1fc7]], [[1fc9|1fc9]], [[1fcf|1fcf]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fc6 OCA], [https://pdbe.org/1fc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fc6 RCSB], [https://www.ebi.ac.uk/pdbsum/1fc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fc6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fc6 OCA], [https://pdbe.org/1fc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fc6 RCSB], [https://www.ebi.ac.uk/pdbsum/1fc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fc6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CTPA_ACUOB CTPA_ACUOB]] Protease involved in the C-terminal processing of the chloroplastic D1 protein of photosystem II. This proteolytic processing is necessary to allow the light-driven assembly of the tetranuclear manganese cluster, which is responsible for photosynthetic water oxidation.<ref>PMID:9252339</ref>
[https://www.uniprot.org/uniprot/CTPA_TETOB CTPA_TETOB] Protease involved in the C-terminal processing of the chloroplastic D1 protein of photosystem II. This proteolytic processing is necessary to allow the light-driven assembly of the tetranuclear manganese cluster, which is responsible for photosynthetic water oxidation.<ref>PMID:9252339</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fc6 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fc6 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We report here the first three-dimensional structure of the D1 C-terminal processing protease (D1P), which is encoded by the ctpA gene. This enzyme removes the C-terminal extension of the D1 polypeptide of photosystem II of oxygenic photosynthesis. Proteolytic processing is necessary to allow the light driven assembly of the tetranuclear manganese cluster, which is responsible for photosynthetic water oxidation. The X-ray structure of the Scenedesmus obliquus enzyme has been determined at 1.8 A resolution using the multiwavelength anomalous dispersion method. The enzyme is monomeric and is composed of three folding domains. The middle domain is topologically homologous to known PDZ motifs and is proposed to be the site at which the substrate C-terminus binds. The remainder of the substrate likely extends across the face of the enzyme, interacting at its scissile bond with the enzyme active site Ser 372 / Lys 397 catalytic dyad, which lies at the center of the protein at the interface of the three domains.
Crystal structures of the photosystem II D1 C-terminal processing protease.,Liao DI, Qian J, Chisholm DA, Jordan DB, Diner BA Nat Struct Biol. 2000 Sep;7(9):749-53. PMID:10966643<ref>PMID:10966643</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1fc6" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Photosystem II|Photosystem II]]
*[[Photosystem II 3D structures|Photosystem II 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Achnanthes obliqua]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chisholm, D A]]
[[Category: Tetradesmus obliquus]]
[[Category: Diner, B A]]
[[Category: Chisholm DA]]
[[Category: Jordan, D B]]
[[Category: Diner BA]]
[[Category: Liao, D I]]
[[Category: Jordan DB]]
[[Category: Qian, J]]
[[Category: Liao DI]]
[[Category: D1 c-terminal processing protease]]
[[Category: Qian J]]
[[Category: Hydrolase]]
[[Category: Pdz domain]]
[[Category: Photosynthesis]]
[[Category: Photosystem ii]]
[[Category: Serine protease]]
[[Category: Serine-lysine catalytic dyad]]
[[Category: X-ray crystal structure]]

Revision as of 13:13, 20 March 2024

PHOTOSYSTEM II D1 C-TERMINAL PROCESSING PROTEASEPHOTOSYSTEM II D1 C-TERMINAL PROCESSING PROTEASE

Structural highlights

1fc6 is a 1 chain structure with sequence from Tetradesmus obliquus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CTPA_TETOB Protease involved in the C-terminal processing of the chloroplastic D1 protein of photosystem II. This proteolytic processing is necessary to allow the light-driven assembly of the tetranuclear manganese cluster, which is responsible for photosynthetic water oxidation.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Trost JT, Chisholm DA, Jordan DB, Diner BA. The D1 C-terminal processing protease of photosystem II from Scenedesmus obliquus. Protein purification and gene characterization in wild type and processing mutants. J Biol Chem. 1997 Aug 15;272(33):20348-56. PMID:9252339

1fc6, resolution 1.80Å

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