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| == Function == | | == Function == |
| [https://www.uniprot.org/uniprot/Q9A1Y0_STRP1 Q9A1Y0_STRP1] | | [https://www.uniprot.org/uniprot/Q9A1Y0_STRP1 Q9A1Y0_STRP1] |
| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| Streptococcus pyogenes, or Group A Streptococcus (GAS), is a pathogenic bacterium that causes a variety of infectious diseases. The GAS genome encodes one protein tyrosine phosphatase, SP-PTP, which plays an essential role in the replication and virulence maintenance of GAS. Herein, we present the crystal structure of SP-PTP at 1.9 A resolution. Although SP-PTP has been reported to have dual phosphatase specificity for both phosphorylated tyrosine and serine/threonine, three-dimensional structural analysis showed that SP-PTP shares high similarity with typical low molecular weight protein tyrosine phosphatases (LMWPTPs), which are specific for phosphotyrosine, but not with dual-specificity phosphatases, in overall folding and active site composition. In the dephosphorylation activity test, SP-PTP consistently acted on phosphotyrosine substrates, but not or only minimally on phosphoserine/phosphothreonine substrates. Collectively, our structural and biochemical analyses verified SP-PTP as a canonical tyrosine-specific LMWPTP.
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| Crystal structure of SP-PTP, a low molecular weight protein tyrosine phosphatase from Streptococcus pyogenes.,Ku B, Keum CW, Lee HS, Yun HY, Shin HC, Kim BY, Kim SJ Biochem Biophys Res Commun. 2016 Aug 19. pii: S0006-291X(16)31352-3. doi:, 10.1016/j.bbrc.2016.08.097. PMID:27545603<ref>PMID:27545603</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 5got" style="background-color:#fffaf0;"></div>
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| ==See Also== | | ==See Also== |
| *[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] | | *[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] |
| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |