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| <StructureSection load='3vty' size='340' side='right'caption='[[3vty]], [[Resolution|resolution]] 2.00Å' scene=''> | | <StructureSection load='3vty' size='340' side='right'caption='[[3vty]], [[Resolution|resolution]] 2.00Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[3vty]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"candidatus_magnetobacterium_bavaricum"_spring_et_al_1993_in_spring_and_schleifer_2001 "candidatus magnetobacterium bavaricum" spring et al 1993 in spring and schleifer 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VTY FirstGlance]. <br> | | <table><tr><td colspan='2'>[[3vty]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candidatus_Magnetobacterium_bavaricum Candidatus Magnetobacterium bavaricum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VTY FirstGlance]. <br> |
| </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vtx|3vtx]]</div></td></tr> | | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MamA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29290 "Candidatus Magnetobacterium bavaricum" Spring et al 1993 in Spring and Schleifer 2001])</td></tr>
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| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vty OCA], [https://pdbe.org/3vty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vty RCSB], [https://www.ebi.ac.uk/pdbsum/3vty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vty ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vty OCA], [https://pdbe.org/3vty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vty RCSB], [https://www.ebi.ac.uk/pdbsum/3vty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vty ProSAT]</span></td></tr> |
| </table> | | </table> |
| <div style="background-color:#fffaf0;">
| | == Function == |
| == Publication Abstract from PubMed == | | [https://www.uniprot.org/uniprot/K7N5L8_9BACT K7N5L8_9BACT] |
| Magnetotactic bacteria enclose the magnetosome, a unique prokaryotic sub-cellular organelle that allows the biomineralization of magnetic nano-crystals. Membrane-coated magnetosomes are arranged into a linear chain that permits magnetotactic bacteria to navigate geomagnetic fields. Magnetosome assembly and biomineralization are controlled by conserved magnetosome-associated proteins, including MamA, a tetra-trico-peptide repeat (TPR)-containing protein that was shown to coat the magnetosome membrane. In this study, two MamA structures from Candidatus Magnetobacterium bavaricum (Mbav) were determined via X-ray crystallography. These structures confirm that Mbav MamA folds as a sequential TPR protein and shares a high degree of structural similarity with homologous MamA proteins from Magnetospirillum species. Furthermore, the two TPR-containing domains of MamA are separated by an interphylum-conserved region containing a flexible hinge that is involved in ligand binding and recognition. Finally, substantial differences were found in the local stabilization of the MamA N-terminal domain as a result of the loss of an evolutionary conserved salt bridge.
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| Inter-phylum structural conservation of the magnetosome-associated TPR-containing protein, MamA.,Zeytuni N, Baran D, Davidov G, Zarivach R J Struct Biol. 2012 Dec;180(3):479-87. doi: 10.1016/j.jsb.2012.08.001. Epub 2012 , Aug 15. PMID:22917855<ref>PMID:22917855</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 3vty" style="background-color:#fffaf0;"></div>
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| == References ==
| |
| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
| [[Category: Candidatus magnetobacterium bavaricum spring et al 1993 in spring and schleifer 2001]] | | [[Category: Candidatus Magnetobacterium bavaricum]] |
| [[Category: Large Structures]] | | [[Category: Large Structures]] |
| [[Category: Baran, D]] | | [[Category: Baran D]] |
| [[Category: Davidov, G]] | | [[Category: Davidov G]] |
| [[Category: Zarivach, R]] | | [[Category: Zarivach R]] |
| [[Category: Zeytuni, N]] | | [[Category: Zeytuni N]] |
| [[Category: Cytosol]]
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| [[Category: Peptide binding protein]]
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| [[Category: Protein binding]]
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| [[Category: Protein-protein interaction]]
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| [[Category: Tpr protein]]
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